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Table 1 Comparison of main clinical features in normal controls and PCOS subjects

From: Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Item Normal control PCOS P-value
Normal weight
(BMI < 25)
Overweight /Obese
(BMI ≥ 25)
N 33 33 34  
SFRP5 (ng/ml) 63.98 ± 12.40 37.99 ± 10.80c 32.77 ± 8.31c  < 0.001
Age(years) 27.97 ± 3.86 26.97 ± 2.82 29.06 ± 3.86 0.293
BMI (Kg/m2) 20.70 ± 2.14 21.62 ± 1.98 28.28 ± 2.40c,f  < 0.001
WHR 0.79 ± 0.03 0.79 ± 0.04 0.84 ± 0.02c,f  < 0.001
AMH (ng/ml) 2.86 ± 0.70 5.52 ± 2.02c 6.62 ± 2.83c  < 0.001
FSH (mIU/ml) 7.58 ± 1.95 6.18 ± 1.87a 6.89 ± 2.21 0.036
LH (mIU/ml) 7.01 ± 1.77 12.46 ± 9.99a 9.42 ± 6.24 0.023
FAI 2.15 ± 0.56 5.98 ± 2.47c 6.92 ± 3.09c  < 0.001
FINS (Uiu/ml) 5.4(4.3,6.5) 5.97(4.85, 9.15) 12.99(10.83,14.85)c,f  < 0.001
2-h INS (Uiu/ml) 18.5(13.22,27.87) 41.2 (33.94,81.95)c 99.49(67.99,138.86)c,e  < 0.001
FBG (mmol/l) 4.91 ± 0.23 5.31 ± 0.33c 5.71 ± 0.61c  < 0.001
2-hBG (mmol/l) 5.74 ± 1.00 7.58 ± 1.92c 9.01 ± 2.30c  < 0.001
TG (mmol/L) 1.00 ± 0.23 1.17 ± 0.58 2.27 ± 0.91c,f  < 0.001
TC (mmol/L) 4.36 ± 0.44 4.49 ± 0.51 4.78 ± 0.53b 0.007
HDL-C (mmol/L) 1.41 ± 0.31 1.28 ± 0.27 1.24 ± 0.22 0.022
LDL-C (mmol/L) 2.55 ± 0.40 2.55 ± 0.34 2.91 ± 0.41b,e 0.056
HbA1c(%) 5.35 ± 0.24 5.60 ± 0.28b 5.77 ± 0.28c  < 0.001
AUCI 75.66(66.10,88.95) 148.82(106.4,255.49)c 265.94(195.23,388.22)c,e  < 0.001
AUCG 18.70 ± 2.40 25.21 ± 4.87c 27.78 ± 4.69c  < 0.001
HOMA-IR 1.17(0.97,1.44) 1.54(1.01, 2.05) 3.28(2.56, 4.06)c,f  < 0.001
IL6(pg/ml) 4.48 ± 2.94 47.65 ± 30.68c 52.30 ± 39.06c  < 0.001
TNFα (ng/ml) 16.08 ± 3.17 61.36 ± 13.68c 61.27 ± 10.95c  < 0.001
  1. Values are presented as mean ± standard deviation (SD) or medians (25th, 75th percentiles)
  2. WHR waist-to-hip ratio, AMH anti-Müllerian hormone, FAI the free androgen index, FBG fasting blood glucose, 2-hBG 2-h blood glucose, FINS fasting insulin, 2-h Ins 2-h plasma insulin after glucose overload, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, AUCI the area under the curve of insulin, AUCG the area under the curve of glucose, HOMA-IR the homeostasis model assessment of IR
  3. P value: total PCOS compared to the control
  4. a,b and c p < 0.05, p < 0.01 and p < 0.001 as compared to the control
  5. d, e and f p < 0.05, p < 0.01 and p < 0.001 as compared to normal weight PCOS (BMI < 25)