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Table 6 Comparison of the clinical outcomes between the two treatment groups of clomiphene-metformin combination

From: Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Item Group I (Clomiphene and Metformin) Group II (Clomiphene alone) P-value
N 37 36  
Ovulation rate (%) 67.6(25) 28.6(8)  < 0.0001
days for follicular development 20.62 ± 1.34 26.69 ± 1.29 0.0017
Endometrial thickness (mm) 8.34 ± 0.34 8.15 ± 0.27 0.6663
Number of dominant follicles(> 14 mm) 1.76 ± 0.28 0.53 ± 0.20 0.0007
Serum estradiol on day of HCG (pg/mL) 564.6 ± 116.2 270.4 ± 62.0 0.0287
HCG positive rate (%) 37.8(14) 19.4(7) 0.1208
Clinical pregnancy rate (%) 29.7(11) 8.3(3) 0.0352
Miscarriage rate (%) 21.4(3) 57.1(4) 0.1564
Multiple pregnancy rate (%) 18.2(2) 33.3(1)