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Table 6 Comparison of the clinical outcomes between the two treatment groups of clomiphene-metformin combination

From: Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Item

Group I (Clomiphene and Metformin)

Group II (Clomiphene alone)

P-value

N

37

36

 

Ovulation rate (%)

67.6(25)

28.6(8)

 < 0.0001

days for follicular development

20.62 ± 1.34

26.69 ± 1.29

0.0017

Endometrial thickness (mm)

8.34 ± 0.34

8.15 ± 0.27

0.6663

Number of dominant follicles(> 14 mm)

1.76 ± 0.28

0.53 ± 0.20

0.0007

Serum estradiol on day of HCG (pg/mL)

564.6 ± 116.2

270.4 ± 62.0

0.0287

HCG positive rate (%)

37.8(14)

19.4(7)

0.1208

Clinical pregnancy rate (%)

29.7(11)

8.3(3)

0.0352

Miscarriage rate (%)

21.4(3)

57.1(4)

0.1564

Multiple pregnancy rate (%)

18.2(2)

33.3(1)