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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: GATA1-induced upregulation of LINC01503 promotes carboplatin resistance in ovarian carcinoma by upregulating PD-L1 via sponging miR-766-5p

Fig. 3

GATA1 activates LINC01503 transcription in CBP-resistant OCa cells. A and B The binding motif of GATA1 and LINC01503 promoter was presented according to the data from JASPAR and UCSC database. C and D RT-qPCR and western blotting were used to detect the mRNA and protein levels of GATA1 in CBP-resistant OCa cells transfected with GATA1 or si-GATA1. E The expression of LINC01503 was detected in OVCAR-3/CBP and CAOV-3/CBP cells by RT-qPCR. F ChIP assay revealed that there was a strong binding affinity of GATA1 and LINC01503 promoter on both 2 sites. G Luciferase reporter assay indicated the interaction between GATA1 and LINC01503 promoter. (n = 3; **P < 0.01)

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Journal of Ovarian Research

ISSN: 1757-2215

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