Fig. 6

PD-L1 is a target of miR-766-5p and can be regulated by LINC01503 via miR-766-5p. A Putative binding regions of miR-766-5p in 3′UTR of PD-L1 was predicted by StarBase. B Luciferase activities of wild-type or mutant PD-L1 in OVCAR-3/CBP and CAOV-3/CBP cells transfected with NC mimics or miR-766-5p mimics were determined by luciferase reporter assay. C and D The mRNA and protein levels of PD-L1 in CBP-resistant OCa cell lines and parental cell lines were detected by RT-qPCR and Western blotting assays. E–H The mRNA and protein levels of PD-L1 were measured by RT-qPCR and western blotting in OVCAR-3/CBP and CAOV-3/CBP cells. (n = 3; *P < 0.05, **P < 0.01)