Skip to main content

Table 1 Clinicopathological characteristics of epithelial ovarian cancer (EOC) patients

From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis

Variable

Total patients (n = 482)

DD-INR score

p-value

DD-INR = 0 (n = 139)

DD-INR = 1 (n = 178)

DD-INR = 2 (n = 165)

Age (years)

57.83 ± 5.93

57.32 ± 6.49

58.20 ± 5.31

57.92 ± 6.18

0.422

BMI (kg/m2)

23.12 ± 1.12

23.02 ± 1.03

22.98 ± 1.09

23.20 ± 1.12

0.144

Menopausal status, n (%)

0.629

 Pre/peri-menopause

170 (35.27%)

52 (10.79%)

58 (12.03%)

60 (12.45%)

-

 Post-menopause

312 (64.73%)

87 (18.05%)

120 (24.90%)

105 (21.78%)

-

Tumor size (cm)

6.21 ± 3.39

5.92 ± 3.87

6.32 ± 4.27

6.15 ± 3.24

0.426

Pathological grade, n (%)

   

0.015

 G1-2

185 (38.38%)

52 (10.79%)

82 (17.01%)

51 (10.58%)

-

 G3

297 (61.62%)

87 (18.05%)

96 (19.92%)

114 (23.65%)

-

Clinical stage, n (%)

    

0.003

 I-II

167 (34.65%)

60 (12.45%)

66 (13.69%)

41 (8.51%)

-

 III-IV

315 (65.35%)

79 (16.39%)

112 (23.24%)

124 (25.73%)

-

Histological type, n (%)

0.112

 Serous

293 (60.79%)

87 (18.05%)

107 (22.20%)

99 (20.54%)

-

 Mucinous

85 (17.63%)

29 (6.02%)

26 (5.39%)

30 (6.22%)

-

 Endometrioid

57 (11.83%)

18 (3.73%)

21 (4.36%)

18 (3.73%)

-

 Others

47 (9.75%)

5 (1.04%)

24 (4.98%)

18 (3.73%)

-

Fibrinogen (g/L)

4.25 ± 1.28

3.92 ± 0.89

4.03 ± 1.08

4.47 ± 1.35

0.021

CA-125 (U/mL)

989.62 ± 392.25

923.18 ± 383.84

997.34 ± 366.27

1040.73 ± 398.27

0.028

CA-199 (U/mL)

129.17 ± 58.73

130.48 ± 49.20

128.49 ± 56.32

126.49 ± 60.59

0.825

HE4 (pmol/L)

531.40 ± 89.04

534.23 ± 80.27

522.49 ± 69.03

540.73 ± 74.52

0.293

APTT (s)

32.74 ± 4.19

32.89 ± 3.72

31.82 ± 4.98

32.25 ± 5.02

0.129

PT (s)

11.43 ± 3.20

12.86 ± 2.94

11.57 ± 3.42

10.40 ± 2.36

 < 0.001

TT (s)

14.72 ± 3.58

15.39 ± 4.02

14.92 ± 3.64

14.45 ± 3.27

0.081

D-dimer (mg/L)

0.64 ± 0.28

0.46 ± 0.23

0.78 ± 0.34

1.09 ± 0.25

 < 0.001

INR

0.97 ± 0.35

1.13 ± 0.74

0.96 ± 0.48

0.75 ± 0.27

 < 0.001

Follow-up (months)

58.83 ± 23.94

60.13 ± 29.85

59.01 ± 20.48

57.85 ± 19.26

0.694

  1. Abbreviation: BMI body mass index, DD-INR the combination of D-dimer and International normalized ratio, AFP Alpha-fetoprotein, CEA Carcinoembryonic antigen, HE4 Human epididymis protein 4, APTT activated partial thromboplastin time, TT thrombin time, PT prothrombin time