Table 1 Clinicopathological characteristics of epithelial ovarian cancer (EOC) patients
From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis
| Variable | Total patients (n = 482) | DD-INR score | p-value | ||
|---|---|---|---|---|---|
| DD-INR = 0 (n = 139) | DD-INR = 1 (n = 178) | DD-INR = 2 (n = 165) | |||
| Age (years) | 57.83 ± 5.93 | 57.32 ± 6.49 | 58.20 ± 5.31 | 57.92 ± 6.18 | 0.422 |
| BMI (kg/m2) | 23.12 ± 1.12 | 23.02 ± 1.03 | 22.98 ± 1.09 | 23.20 ± 1.12 | 0.144 |
| Menopausal status, n (%) | 0.629 | ||||
| Pre/peri-menopause | 170 (35.27%) | 52 (10.79%) | 58 (12.03%) | 60 (12.45%) | - |
| Post-menopause | 312 (64.73%) | 87 (18.05%) | 120 (24.90%) | 105 (21.78%) | - |
| Tumor size (cm) | 6.21 ± 3.39 | 5.92 ± 3.87 | 6.32 ± 4.27 | 6.15 ± 3.24 | 0.426 |
| Pathological grade, n (%) | 0.015 | ||||
| G1-2 | 185 (38.38%) | 52 (10.79%) | 82 (17.01%) | 51 (10.58%) | - |
| G3 | 297 (61.62%) | 87 (18.05%) | 96 (19.92%) | 114 (23.65%) | - |
| Clinical stage, n (%) | 0.003 | ||||
| I-II | 167 (34.65%) | 60 (12.45%) | 66 (13.69%) | 41 (8.51%) | - |
| III-IV | 315 (65.35%) | 79 (16.39%) | 112 (23.24%) | 124 (25.73%) | - |
| Histological type, n (%) | 0.112 | ||||
| Serous | 293 (60.79%) | 87 (18.05%) | 107 (22.20%) | 99 (20.54%) | - |
| Mucinous | 85 (17.63%) | 29 (6.02%) | 26 (5.39%) | 30 (6.22%) | - |
| Endometrioid | 57 (11.83%) | 18 (3.73%) | 21 (4.36%) | 18 (3.73%) | - |
| Others | 47 (9.75%) | 5 (1.04%) | 24 (4.98%) | 18 (3.73%) | - |
| Fibrinogen (g/L) | 4.25 ± 1.28 | 3.92 ± 0.89 | 4.03 ± 1.08 | 4.47 ± 1.35 | 0.021 |
| CA-125 (U/mL) | 989.62 ± 392.25 | 923.18 ± 383.84 | 997.34 ± 366.27 | 1040.73 ± 398.27 | 0.028 |
| CA-199 (U/mL) | 129.17 ± 58.73 | 130.48 ± 49.20 | 128.49 ± 56.32 | 126.49 ± 60.59 | 0.825 |
| HE4 (pmol/L) | 531.40 ± 89.04 | 534.23 ± 80.27 | 522.49 ± 69.03 | 540.73 ± 74.52 | 0.293 |
| APTT (s) | 32.74 ± 4.19 | 32.89 ± 3.72 | 31.82 ± 4.98 | 32.25 ± 5.02 | 0.129 |
| PT (s) | 11.43 ± 3.20 | 12.86 ± 2.94 | 11.57 ± 3.42 | 10.40 ± 2.36 | < 0.001 |
| TT (s) | 14.72 ± 3.58 | 15.39 ± 4.02 | 14.92 ± 3.64 | 14.45 ± 3.27 | 0.081 |
| D-dimer (mg/L) | 0.64 ± 0.28 | 0.46 ± 0.23 | 0.78 ± 0.34 | 1.09 ± 0.25 | < 0.001 |
| INR | 0.97 ± 0.35 | 1.13 ± 0.74 | 0.96 ± 0.48 | 0.75 ± 0.27 | < 0.001 |
| Follow-up (months) | 58.83 ± 23.94 | 60.13 ± 29.85 | 59.01 ± 20.48 | 57.85 ± 19.26 | 0.694 |