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Table 1 Clinicopathological characteristics of epithelial ovarian cancer (EOC) patients

From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis

Variable Total patients (n = 482) DD-INR score p-value
DD-INR = 0 (n = 139) DD-INR = 1 (n = 178) DD-INR = 2 (n = 165)
Age (years) 57.83 ± 5.93 57.32 ± 6.49 58.20 ± 5.31 57.92 ± 6.18 0.422
BMI (kg/m2) 23.12 ± 1.12 23.02 ± 1.03 22.98 ± 1.09 23.20 ± 1.12 0.144
Menopausal status, n (%) 0.629
 Pre/peri-menopause 170 (35.27%) 52 (10.79%) 58 (12.03%) 60 (12.45%) -
 Post-menopause 312 (64.73%) 87 (18.05%) 120 (24.90%) 105 (21.78%) -
Tumor size (cm) 6.21 ± 3.39 5.92 ± 3.87 6.32 ± 4.27 6.15 ± 3.24 0.426
Pathological grade, n (%)     0.015
 G1-2 185 (38.38%) 52 (10.79%) 82 (17.01%) 51 (10.58%) -
 G3 297 (61.62%) 87 (18.05%) 96 (19.92%) 114 (23.65%) -
Clinical stage, n (%)      0.003
 I-II 167 (34.65%) 60 (12.45%) 66 (13.69%) 41 (8.51%) -
 III-IV 315 (65.35%) 79 (16.39%) 112 (23.24%) 124 (25.73%) -
Histological type, n (%) 0.112
 Serous 293 (60.79%) 87 (18.05%) 107 (22.20%) 99 (20.54%) -
 Mucinous 85 (17.63%) 29 (6.02%) 26 (5.39%) 30 (6.22%) -
 Endometrioid 57 (11.83%) 18 (3.73%) 21 (4.36%) 18 (3.73%) -
 Others 47 (9.75%) 5 (1.04%) 24 (4.98%) 18 (3.73%) -
Fibrinogen (g/L) 4.25 ± 1.28 3.92 ± 0.89 4.03 ± 1.08 4.47 ± 1.35 0.021
CA-125 (U/mL) 989.62 ± 392.25 923.18 ± 383.84 997.34 ± 366.27 1040.73 ± 398.27 0.028
CA-199 (U/mL) 129.17 ± 58.73 130.48 ± 49.20 128.49 ± 56.32 126.49 ± 60.59 0.825
HE4 (pmol/L) 531.40 ± 89.04 534.23 ± 80.27 522.49 ± 69.03 540.73 ± 74.52 0.293
APTT (s) 32.74 ± 4.19 32.89 ± 3.72 31.82 ± 4.98 32.25 ± 5.02 0.129
PT (s) 11.43 ± 3.20 12.86 ± 2.94 11.57 ± 3.42 10.40 ± 2.36  < 0.001
TT (s) 14.72 ± 3.58 15.39 ± 4.02 14.92 ± 3.64 14.45 ± 3.27 0.081
D-dimer (mg/L) 0.64 ± 0.28 0.46 ± 0.23 0.78 ± 0.34 1.09 ± 0.25  < 0.001
INR 0.97 ± 0.35 1.13 ± 0.74 0.96 ± 0.48 0.75 ± 0.27  < 0.001
Follow-up (months) 58.83 ± 23.94 60.13 ± 29.85 59.01 ± 20.48 57.85 ± 19.26 0.694
  1. Abbreviation: BMI body mass index, DD-INR the combination of D-dimer and International normalized ratio, AFP Alpha-fetoprotein, CEA Carcinoembryonic antigen, HE4 Human epididymis protein 4, APTT activated partial thromboplastin time, TT thrombin time, PT prothrombin time