Table 2 Univariate and multivariate cox hazards survival analysis for recurrence-free survival (RFS) in epithelial ovarian cancer (EOC) patients
From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis
Variables | Univariate regression analysis | Multivariate regression analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age | 1.217(1.063–1.856) | 0.037 | 1.138(0.956–1.573) | 0.089 |
BMI | 1.159(0.842–1.985) | 0.251 | - | - |
Tumor size | 1.246(1.059–1.725) | 0.028 | 1.382(1.194–1.857) | 0.042 |
Pathological grade | ||||
 G1-2 | Reference | - | Reference | - |
 G3 | 1.483(1.162–2.058) | 0.018 | 1.385(1.272–1.988) | 0.029 |
Clinical stage | ||||
 I-II | Reference | - | Reference | - |
 III-IV | 1.894(1.360–2.753) | 0.009 | 1.921(1.254–3.102) | 0.015 |
Histological type | ||||
 Serous | Reference | - | - | - |
 Others | 1.093(0.849–1.382) | 0.135 | - | - |
Neutrophil | 1.241(1.075–1.793) | 0.036 | 1.205(0.947–1.630) | 0.132 |
lymphocyte | 0.794(0.524–0.989) | 0.032 | 0.837(0.463–1.024) | 0.098 |
Platelet | 1.084(0.937–1.421) | 0.245 | - | - |
Fibrinogen | 1.329(1.125–1.895) | 0.014 | 1.297(1.106–1.924) | 0.033 |
CA-125 | 1.420(1.193–1.614) | 0.009 | 1.398(1.082–1.653) | 0.026 |
CA-199 | 0.992(0.854–1.228) | 0.236 | - | - |
AFP | 1.362(0.937–1.468) | 0.368 | - | - |
CEA | 1.049(0.732–1.840) | 0.493 | - | - |
HE4 | 1.372(1.004–1.738) | 0.034 | 1.304(0.893–1.786) | 0.103 |
DD-INR group | ||||
 0 | Reference | - | Reference | - |
 1 | 1.463(1.192–1.847) | 0.019 | 1.456(1.164–2.048) | 0.021 |
 2 | 2.419(1.738–3.580) | 0.002 | 2.453(1.648–3.788) | 0.009 |
APTT | 0.893(0.473–0.983) | 0.037 | 0.837(0.452–1.284) | 0.242 |
TT | 0.982(0.748–1.240) | 0.139 | - | - |