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Table 2 Univariate and multivariate cox hazards survival analysis for recurrence-free survival (RFS) in epithelial ovarian cancer (EOC) patients

From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis

Variables Univariate regression analysis Multivariate regression analysis
HR (95% CI) P-value HR (95% CI) P-value
Age 1.217(1.063–1.856) 0.037 1.138(0.956–1.573) 0.089
BMI 1.159(0.842–1.985) 0.251 - -
Tumor size 1.246(1.059–1.725) 0.028 1.382(1.194–1.857) 0.042
Pathological grade
 G1-2 Reference - Reference -
 G3 1.483(1.162–2.058) 0.018 1.385(1.272–1.988) 0.029
Clinical stage
 I-II Reference - Reference -
 III-IV 1.894(1.360–2.753) 0.009 1.921(1.254–3.102) 0.015
Histological type
 Serous Reference - - -
 Others 1.093(0.849–1.382) 0.135 - -
Neutrophil 1.241(1.075–1.793) 0.036 1.205(0.947–1.630) 0.132
lymphocyte 0.794(0.524–0.989) 0.032 0.837(0.463–1.024) 0.098
Platelet 1.084(0.937–1.421) 0.245 - -
Fibrinogen 1.329(1.125–1.895) 0.014 1.297(1.106–1.924) 0.033
CA-125 1.420(1.193–1.614) 0.009 1.398(1.082–1.653) 0.026
CA-199 0.992(0.854–1.228) 0.236 - -
AFP 1.362(0.937–1.468) 0.368 - -
CEA 1.049(0.732–1.840) 0.493 - -
HE4 1.372(1.004–1.738) 0.034 1.304(0.893–1.786) 0.103
DD-INR group
 0 Reference - Reference -
 1 1.463(1.192–1.847) 0.019 1.456(1.164–2.048) 0.021
 2 2.419(1.738–3.580) 0.002 2.453(1.648–3.788) 0.009
APTT 0.893(0.473–0.983) 0.037 0.837(0.452–1.284) 0.242
TT 0.982(0.748–1.240) 0.139 - -
  1. Abbreviation: BMI body mass index, DD-INR the combination of D-dimer and International normalized ratio, AFP Alpha-fetoprotein, CEA Carcinoembryonic antigen, HE4 Human epididymis protein 4, APTT activated partial thromboplastin time, TT thrombin time, HR hazard ratio, 95% CI 95% confidence interval