Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway

Table 1 Correlation of the expression of hsa_circ_0004712, miR-331-3p, FZD4 and clinicopathologic features in patients with ovarian cancer

Parameters		hsa_circ_0004712 expression		P-value		miR-331-3p expression		P-value		FZD4 expression		P-value
Parameters	N = 30	High N = 15	Low N = 15	P-value	N = 30	High N = 15	Low N = 15	P-value	N = 30	High N = 15	Low N = 15	P-value
Age, years
< 60	16	7	9	0.464	16	6	10	0.143	16	8	7	0.858
≥ 60	14	8	6		14	9	5		14	7	7
Tumor size
< 4 cm	19	9	10	0.705	19	8	11	0.256	19	7	12	0.058
≥ 4 cm	11	6	5		11	7	4		11	8	3
Histological classification
Serous	20	9	11	0.439	20	12	8	0.121	20	11	9	0.439
Mucinous	10	6	4		10	3	7		10	4	6
Grade
G1	12	3	9	0.025*	12	8	4	0.136	12	2	10	0.003*
G2 + G3	18	12	6		18	7	11		18	13	5
FIGO stage
< III	13	4	9	0.065	13	8	5	0.26	13	3	10	0.010 *
≥ III	17	11	6		17	7	10		17	12	5
Lymph node metastasis
Yes	19	13	6	0.008*	19	7	12	0.058	19	12	7	0.017*
No	11	2	9		11	8	3		11	2	9
Chemosensitivity
Yes	12	5	7	0.456	12	7	5	0.456	12	4	8	0.136
No	18	10	8		18	8	10		18	11	7

ISSN: 1757-2215