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Table 2 Distribution of peripheral lymphocyte subpopulations in the two cohorts before and after surgery

From: Changes in peripheral lymphocyte populations in patients with advanced/recurrent ovarian cancer undergoing splenectomy during cytoreductive surgery

Peripheral lymphocyte subsets Splenectomy group Non-splenectomy group P 1 P 2
pre post P 3 pre post P 4
Percentage (%)
T cells (CD3+) 67.8 (17.3) 68.9 (16.0) 0.241 67.6 (14.48) 69.1 (12.9) 0.276 0.680 0.431
CD3+CD8+ 30.1 (12.2) 26.2 (16.5) 0.210 25.2 (12.50) 27.1 (14.5) 0.056 0.109 0.289
CD8+CD28+ 8.9 (4.1) 7.6 (3.9) 0.011 6.9 (4.3) 6.8 (3.4) 0.022 0.116 0.606
CD3+CD4+ 37.7 (7.1) 35.5 (9.2) 0.768 38.2 (12.8) 39.7 (12.8) 0.292 0.616 0.070
Tregs (CD4+CD25+CD127low) 13.2 (3.3) 14.6 (4.1) 0.344 12.8 (4.0) 13.2 (4.2) 0.005 0.477 0.461
CD4/CD8 1.2 (0.8) 1.2 (0.8) 0.746 1.6 (0.9) 1.7 (1.3) 0.038 0.125 0.048
NK cells (CD3−CD16+56+) 16.1 (12.9) 11.2 (13.9) 0.312 15.8 (14.0) 13.5 (13.3) 0.043 0.721 0.563
B cells (CD3−CD19+) 10.5 (9.5) 11.4 (8.6) 0.922 11.3 (6.9) 13.9 (7.7)  <  0.001 0.880 0.195
HLA-DR+ 22.5 (13.6) 26.2 (19.1) 0.011 22.8 (18.2) 26.3 (15.8) 0.003 0.812 0.864
CD3+/HLA-DR+ 6.3 (17.4) 9.3 (19.4) 0.001 11.3 (13.9) 11.3 (14.6) 0.198 0.563 0.969
CD3−/HLA-DR+ 10.3 (8.5) 13.7 (11.2) 0.177 11.6 (6.8) 13.6 (6.3) 0.010 0.570 0.843
CD3+/HLA-DR− 59.2 (17.3) 49.6 (22.6)  <  0.001 57.4 (17.2) 55.9 (18.6) 0.002 0.669 0.093
Absolute number (cell/ul)
T cells (CD3+) 942 (522) 1079 (502) 0.522 1101 (466) 821 (543)  <  0.001 0.226 0.013
CD3+CD8+ 406 (290) 411 (261) 0.709 416 (251) 313 (237)  <  0.001 0.868 0.012
CD3+CD4+ 495 (273) 611 (263) 0.490 594 (416) 465 (311)  <  0.001 0.111 0.140
NK cells (CD3−CD16+56+) 201 (47) 161 (276) 0.595 255 (236) 162 (173)  <  0.001 0.250 0.510
B cells (CD3−CD19+) 152 (194) 149 (158) 0.241 164 (133) 160 (147) 0.380 0.572 0.570
  1. P 2 = Splenectomy vs. Control after surgery; P 3 = Preoperative vs. Postoperative in the splenectomy cohort; P 4 = Preoperative vs. Postoperative in the control cohort
  2. a Numbers were presented as median (quartile range)
  3. b Pre = before surgery; Post = after surgery
  4. c P values with statistical significance were denoted. P 1 = Splenectomy vs. Control before surgery
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Journal of Ovarian Research

ISSN: 1757-2215

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