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Table 2 Distribution of peripheral lymphocyte subpopulations in the two cohorts before and after surgery

From: Changes in peripheral lymphocyte populations in patients with advanced/recurrent ovarian cancer undergoing splenectomy during cytoreductive surgery

Peripheral lymphocyte subsets

Splenectomy group

Non-splenectomy group

P 1

P 2

pre

post

P 3

pre

post

P 4

Percentage (%)

T cells (CD3+)

67.8 (17.3)

68.9 (16.0)

0.241

67.6 (14.48)

69.1 (12.9)

0.276

0.680

0.431

CD3+CD8+

30.1 (12.2)

26.2 (16.5)

0.210

25.2 (12.50)

27.1 (14.5)

0.056

0.109

0.289

CD8+CD28+

8.9 (4.1)

7.6 (3.9)

0.011

6.9 (4.3)

6.8 (3.4)

0.022

0.116

0.606

CD3+CD4+

37.7 (7.1)

35.5 (9.2)

0.768

38.2 (12.8)

39.7 (12.8)

0.292

0.616

0.070

Tregs (CD4+CD25+CD127low)

13.2 (3.3)

14.6 (4.1)

0.344

12.8 (4.0)

13.2 (4.2)

0.005

0.477

0.461

CD4/CD8

1.2 (0.8)

1.2 (0.8)

0.746

1.6 (0.9)

1.7 (1.3)

0.038

0.125

0.048

NK cells (CD3−CD16+56+)

16.1 (12.9)

11.2 (13.9)

0.312

15.8 (14.0)

13.5 (13.3)

0.043

0.721

0.563

B cells (CD3−CD19+)

10.5 (9.5)

11.4 (8.6)

0.922

11.3 (6.9)

13.9 (7.7)

 <  0.001

0.880

0.195

HLA-DR+

22.5 (13.6)

26.2 (19.1)

0.011

22.8 (18.2)

26.3 (15.8)

0.003

0.812

0.864

CD3+/HLA-DR+

6.3 (17.4)

9.3 (19.4)

0.001

11.3 (13.9)

11.3 (14.6)

0.198

0.563

0.969

CD3−/HLA-DR+

10.3 (8.5)

13.7 (11.2)

0.177

11.6 (6.8)

13.6 (6.3)

0.010

0.570

0.843

CD3+/HLA-DR−

59.2 (17.3)

49.6 (22.6)

 <  0.001

57.4 (17.2)

55.9 (18.6)

0.002

0.669

0.093

Absolute number (cell/ul)

T cells (CD3+)

942 (522)

1079 (502)

0.522

1101 (466)

821 (543)

 <  0.001

0.226

0.013

CD3+CD8+

406 (290)

411 (261)

0.709

416 (251)

313 (237)

 <  0.001

0.868

0.012

CD3+CD4+

495 (273)

611 (263)

0.490

594 (416)

465 (311)

 <  0.001

0.111

0.140

NK cells (CD3−CD16+56+)

201 (47)

161 (276)

0.595

255 (236)

162 (173)

 <  0.001

0.250

0.510

B cells (CD3−CD19+)

152 (194)

149 (158)

0.241

164 (133)

160 (147)

0.380

0.572

0.570

  1. P 2 = Splenectomy vs. Control after surgery; P 3 = Preoperative vs. Postoperative in the splenectomy cohort; P 4 = Preoperative vs. Postoperative in the control cohort
  2. a Numbers were presented as median (quartile range)
  3. b Pre = before surgery; Post = after surgery
  4. c P values with statistical significance were denoted. P 1 = Splenectomy vs. Control before surgery
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Journal of Ovarian Research

ISSN: 1757-2215

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