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Table 1 Demographic characteristics of women in the four groups

From: Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients

Variable Group 1 Group 2 Group 3 Group 4 p-value
Number of patients, n (%) 17,504 (91.0) 835(4.3) 446(2.3) 454(2.4)  
Maternal age, y 30.36 ± 4.15a 32.97 ± 4.80 33.17 ± 4.79 33.83 ± 5.27  < 0.001
Body mass index, kg/m2 21.87 ± 2.97 22.35 ± 3.20* 21.75 ± 2.84* 21.85 ± 3.14  < 0.001
Baseline FSH, mIU/mL 7.33 ± 1.87 9.10 ± 3.51 8.53 ± 2.76 10.52 ± 4.78  < 0.001
Antral follicle count (AFC) 15.05 ± 6.56 7.64 ± 2.77* 3.31 ± 0.95* 3.18 ± 0.93  < 0.001
AMH level, ng/ml 6.04 ± 4.15 0.86 ± 0.24* 2.46 ± 1.41* 0.69 ± 0.30  < 0.001
Duration of infertility, years 3.38 ± 2.46 3.41 ± 2.93 3.67 ± 2.95 3.45 ± 3.15 0.012
Infertility diagnosis       < 0.001
Primary infertility, % 67.2a
(11,767/17504)
59.6 (498/835) 57.8 (258/446) 58.1 (264/454)  
Secondary infertility, % 32.8a (5737/17504) 40.4 (337/835) 42.2 (188/446) 41.9
(190/454)
 
Infertility etiology, %       < 0.001
Male factor 23.9 (4176/17504) 15.6 (130/835) 12.8
(57/446)
14.1
(64/454)
 
Tubal factor 46.6 (8158/17504) 36.8 (307/835) 32.1 (143/446) 29.7
(135/454)
 
Ovulatory 9.6 (1675/17504) 0.2
(2/835)
0.9
(4/446)
0.4
(2/454)
 
Diminished ovarian reserve 4.8 (433/17504) 41.3(345/835) 47.5(212/446) 52.9
(240/454)
 
Unexplained/Other 15.2 (2662/17504) 6.1
(51/835)
6.7
(30/446)
2.9
(13/454)
 
Ovarian stimulation protocols       < 0.001
GnRH Antagonist, % 20.4a
(3576/17504)
75.8*
(633/835)
92.8*
(414/446)
97.1
(441/454)
 
Long GnRH-a, % 29.5a
(5170/17504)
13.9*(116/835) 2.7*(12/446) 0.2
(1/454)
 
GnRH-a ultra-long, % 50.1a(8766/17504) 10.3*(86/835) 4.5*(20/446) 2.6(12/454)  
Gn duration, days 10.49 ± 1.94 9.73 ± 1.67 9.55 ± 1.64 9.26 ± 2.01  < 0.001
Gonadotropin dose, IU 2311 ± 835a 2921 ± 781 2799 ± 713 2813 ± 902  < 0.001
E2 on hCG, pg/mL 3137 ± 1900a 1618 ± 930* 1980 ± 1105* 1288 ± 729  < 0.001
P on hCG day, ng/mL 0.92 ± 0.54a 0.74 ± 0.39* 0.83 ± 0.44* 0.72 ± 0.49  < 0.001
No. of oocytes retrieved 13.65 ± 6.54a 6.23 ± 3.63 6.94 ± 3.67 4.34 ± 2.59  < 0.001
No. of MII oocytes 11.87 ± 5.92a 5.48 ± 3.27 6.20 ± 3.43 3.85 ± 2.43  < 0.001
Poor ovarian response, % 2.6a (455/17504) 24.0* (200/835) 18.6*
(83/446)
43.0
(195/454)
 < 0.001
Suboptimal ovarian response, % 25.9a (4525/17504) 60.5 (505/835) 59.6
(266/446)
52.9
(240/454)
 < 0.001
Oocyte maturation rate 0.87 ± 0.14a 0.89 ± 0.17 0.90 ± 0.15 0.88 ± 0.22  < 0.001
The number of 2PN 8.18 ± 4.71 3.75 ± 2.70 4.27 ± 2.83 2.74 ± 2.14  < 0.001
Normal fertilization rate 0.64 ± 0.21 0.63 ± 0.28 0.65 ± 0.26 0.63 ± 0.32 0.290
Good-quality embryo rate on day 3 0.50 ± 0.27 0.49 ± 0.33 0.51 ± 0.35 0.49 ± 0.36 0.972
blastocyst formation rate 0.63 ± 0.29 0.56 ± 0.37 0.61 ± 0.35 0.46 ± 0.40  < 0.001
No. of available embryos 8.14 ± 4.78 3.75 ± 2.66 4.26 ± 2.76 2.78 ± 2.16  < 0.001
Available embryo rate 0.64 ± 0.22 0.63 ± 0.28 0.66 ± 0.28 0.64 ± 0.32 0.027
No. of embryos transferred 1.01 ± 0.78 1.06 ± 0.76 0.94 ± 0.76 0.88 ± 0.80  < 0.001
Endometrial thickness, mm 11.90 ± 2.64 11.02 ± 2.55 10.88 ± 2.49 10.84 ± 2.50  < 0.001
Cumulative live birth rate, % 57.8(10,120/17504) 37.5(313/835) 36.3(162/446) 28.2(128/454)  < 0.001
Live birth rate, %b 33.8a (5924/17483) 28.9 (241/834) 23.5
(105/445)
20.0 c
(91/454)
 < 0.001
Live birth rate, %c 48.2
(5924/12286)
39.2 (241/615) 34.5 (105/304) 32.6
(91/279)
 < 0.001
Clinical pregnancy rate, %b 39.1a (6845/17504) 35.0 (292/835) 28.3
(126/446)
23.3c
(106/454)
 < 0.001
Clinical pregnancy rate, %c 55.6a (6845/12307) 47.4 (292/616) 41.3 (126/305) 38.0
(106/279)
 < 0.001
  1. *Group 2 and Group 3 have significant differences after Bonferroni correction. (P < 0.05)
  2. a < 0.001, group A versus other groups b Per started cycle c Per embryo transfer