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Table 2 Basic and cycle characteristics and pregnancy outcomes in the different controlled ovarian stimulation protocols in Group 2

From: Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients

Variable GnRH Antagonist(A) Long GnRH-a(B) GnRH-a ultra-long (C) Overall p value A vs B A vs C B vs C
Number of patients, n (%) 633(75.8) 116(13.9) 86(10.3)     
Maternal age, y 33.22 ± 4.88 32.97 ± 4.58 31.14 ± 4.07 0.001 1.00  < 0.001* 0.016*
Body mass index, kg/m2 22.31 ± 3.24 22.48 ± 2.94 22.49 ± 3.20 0.508    
Baseline FSH, mIU/mL 9.32 ± 3.74 8.18 ± 2.25 8.67 ± 2.90 0.016 0.024* 0.447 1.00
Antral follicle count (AFC) 7.07 ± 2.37 9.01 ± 2.64 10.01 ± 3.70  < 0.001  < 0.001*  < 0.001* 1.00
AMH level, ng/ml 0.84 ± 0.24 0.93 ± 0.20 0.92 ± 0.25  < 0.001  < 0.001* 0.001* 1.00
Duration of infertility, years 3.36 ± 3.01 3.58 ± 2.81 3.47 ± 2.46 0.208    
Infertility diagnosis     0.351    
Primary infertility, % 61.0(386/633) 54.3(63/116) 57.0(49/86)     
Secondary infertility, % 39.0(247/633) 45.7(53/116) 43.0(37/86)     
Gn duration, days 9.48 ± 1.53 10.09 ± 1.87 11.03 ± 1.70  < 0.001 0.004  < 0.001*  < 0.001*
Gonadotropin dose, IU 2883 ± 768 2878 ± 786 3257 ± 790  < 0.001 1.00 0.001*  < 0.001*
E2 on hCG, pg/mL 1558 ± 885 1949 ± 1049 1618 ± 996 0.001  < 0.001* 1.00 0.039*
P on hCG day, ng/mL 0.73 ± 0.39 0.78 ± 0.38 0.73 ± 0.37 0.223  < 0.001* 1.00 0.039*
No. of oocytes retrieved 5.87 ± 3.36 6.95 ± 3.66 7.91 ± 4.80  < 0.001 0.007*  < 0.001* 0.960
No. of MII oocytes 5.20 ± 3.03 5.93 ± 3.21 6.94 ± 4.40  < 0.001 0.056 0.001* 0.690
Oocyte maturation rate 0.90 ± 0.16 0.87 ± 0.19 0.88 ± 0.15 0.054    
The number of 2PN 3.58 ± 2.54 3.92 ± 2.62 4.78 ± 3.57 0.015 0.434 0.022* 0.781
Normal fertilization rate 0.64 ± 0.28 0.59 ± 0.27 0.64 ± 0.24 0.208    
Good-quality embryo rate on day 3 0.50 ± 0.34 0.44 ± 0.31 0.48 ± 0.27 0.557    
blastocyst formation rate 0.56 ± 0.38 0.54 ± 0.36 0.54 ± 0.35 0.737    
No. of available embryos 3.58 ± 2.49 3.94 ± 2.61 4.76 ± 3.58 0.017 0.412 0.027* 0.872
Available embryo rate 0.64 ± 0.28 0.60 ± 0.26 0.63 ± 0.24 0.207    
No. of embryos transferred 1.00 ± 0.76 1.24 ± 0.81 1.19 ± 0.68 0.002 0.005* 0.126 1.00
Endometrial thickness, mm 10.92 ± 2.57 11.40 ± 2.51 11.28 ± 2.38 0.022 0.068 0.182 1.00
Cumulative live birth rate, % 35.5(225/633) 37.9(44/116) 51.2(44/86) 0.019 1.00 0.015* 0.165
Live birth rate, %b 26.2(166/633) 31.3(36/115) 45.3(39/86) 0.001 0.808 0.001* 0.090
Live birth rate, %c 36.6(166/454) 40.9(36/88) 53.4(39/73) 0.022 1.00 0.019* 0.317
Clinical pregnancy rate, %b 32.2(204/633) 37.9(44/116) 51.2(44/86) 0.002 0.710 0.002* 0.154
Clinical pregnancy rate, %c 44.9(204/454) 49.4(44/89) 60.3(44/73) 0.047 1.00 0.045* 0.509
  1. * Significant differences after Bonferroni correction (P < 0.05)
  2. b Per started cycle
  3. c Per embryo transfer