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Table 2 Basic and cycle characteristics and pregnancy outcomes in the different controlled ovarian stimulation protocols in Group 2

From: Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients

Variable

GnRH Antagonist(A)

Long GnRH-a(B)

GnRH-a ultra-long (C)

Overall p value

A vs B

A vs C

B vs C

Number of patients, n (%)

633(75.8)

116(13.9)

86(10.3)

    

Maternal age, y

33.22 ± 4.88

32.97 ± 4.58

31.14 ± 4.07

0.001

1.00

 < 0.001*

0.016*

Body mass index, kg/m2

22.31 ± 3.24

22.48 ± 2.94

22.49 ± 3.20

0.508

   

Baseline FSH, mIU/mL

9.32 ± 3.74

8.18 ± 2.25

8.67 ± 2.90

0.016

0.024*

0.447

1.00

Antral follicle count (AFC)

7.07 ± 2.37

9.01 ± 2.64

10.01 ± 3.70

 < 0.001

 < 0.001*

 < 0.001*

1.00

AMH level, ng/ml

0.84 ± 0.24

0.93 ± 0.20

0.92 ± 0.25

 < 0.001

 < 0.001*

0.001*

1.00

Duration of infertility, years

3.36 ± 3.01

3.58 ± 2.81

3.47 ± 2.46

0.208

   

Infertility diagnosis

   

0.351

   

Primary infertility, %

61.0(386/633)

54.3(63/116)

57.0(49/86)

    

Secondary infertility, %

39.0(247/633)

45.7(53/116)

43.0(37/86)

    

Gn duration, days

9.48 ± 1.53

10.09 ± 1.87

11.03 ± 1.70

 < 0.001

0.004

 < 0.001*

 < 0.001*

Gonadotropin dose, IU

2883 ± 768

2878 ± 786

3257 ± 790

 < 0.001

1.00

0.001*

 < 0.001*

E2 on hCG, pg/mL

1558 ± 885

1949 ± 1049

1618 ± 996

0.001

 < 0.001*

1.00

0.039*

P on hCG day, ng/mL

0.73 ± 0.39

0.78 ± 0.38

0.73 ± 0.37

0.223

 < 0.001*

1.00

0.039*

No. of oocytes retrieved

5.87 ± 3.36

6.95 ± 3.66

7.91 ± 4.80

 < 0.001

0.007*

 < 0.001*

0.960

No. of MII oocytes

5.20 ± 3.03

5.93 ± 3.21

6.94 ± 4.40

 < 0.001

0.056

0.001*

0.690

Oocyte maturation rate

0.90 ± 0.16

0.87 ± 0.19

0.88 ± 0.15

0.054

   

The number of 2PN

3.58 ± 2.54

3.92 ± 2.62

4.78 ± 3.57

0.015

0.434

0.022*

0.781

Normal fertilization rate

0.64 ± 0.28

0.59 ± 0.27

0.64 ± 0.24

0.208

   

Good-quality embryo rate on day 3

0.50 ± 0.34

0.44 ± 0.31

0.48 ± 0.27

0.557

   

blastocyst formation rate

0.56 ± 0.38

0.54 ± 0.36

0.54 ± 0.35

0.737

   

No. of available embryos

3.58 ± 2.49

3.94 ± 2.61

4.76 ± 3.58

0.017

0.412

0.027*

0.872

Available embryo rate

0.64 ± 0.28

0.60 ± 0.26

0.63 ± 0.24

0.207

   

No. of embryos transferred

1.00 ± 0.76

1.24 ± 0.81

1.19 ± 0.68

0.002

0.005*

0.126

1.00

Endometrial thickness, mm

10.92 ± 2.57

11.40 ± 2.51

11.28 ± 2.38

0.022

0.068

0.182

1.00

Cumulative live birth rate, %

35.5(225/633)

37.9(44/116)

51.2(44/86)

0.019

1.00

0.015*

0.165

Live birth rate, %b

26.2(166/633)

31.3(36/115)

45.3(39/86)

0.001

0.808

0.001*

0.090

Live birth rate, %c

36.6(166/454)

40.9(36/88)

53.4(39/73)

0.022

1.00

0.019*

0.317

Clinical pregnancy rate, %b

32.2(204/633)

37.9(44/116)

51.2(44/86)

0.002

0.710

0.002*

0.154

Clinical pregnancy rate, %c

44.9(204/454)

49.4(44/89)

60.3(44/73)

0.047

1.00

0.045*

0.509

  1. * Significant differences after Bonferroni correction (P < 0.05)
  2. b Per started cycle
  3. c Per embryo transfer
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Journal of Ovarian Research

ISSN: 1757-2215

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