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Table 3 Basic and cycle characteristics and pregnancy outcomes in the different controlled ovarian stimulation protocols in Group 3

From: Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients

Variable GnRH Antagonist(A) Long GnRH-a(B) GnRH-a ultra-long(C) Overall p value A vs B A vs C B vs C
Number of patients, n (%) 414(92.8) 12(2.7) 20(4.5)     
Maternal age, y 33.21 ± 4.80 34.08 ± 4.30 31.80 ± 4.94 0.328    
Body mass index, kg/m2 21.74 ± 2.87 21.73 ± 2.61 21.85 ± 2.38 0.965    
Baseline FSH, mIU/mL 8.62 ± 2.80 7.18 ± 1.55 7.53 ± 2.15 0.030 1.00 0.134 0.221
Antral follicle count (AFC) 3.32 ± 0.91 3.17 ± 1.40 3.25 ± 1.33 0.828    
AMH level, ng/ml 2.38 ± 1.32 4.01 ± 2.45 3.28 ± 1.75 0.002 0.044* 0.025* 1.00
Duration of infertility, years, median (IQR) 3.00(2.00–5.00) 3.00(1.00–4.00) 2.00(1.00–4.00) 0.276    
Infertility diagnosis     0.224    
Primary infertility, % 56.8(235/414) 66.7(8/12) 75.0(15/20)     
Secondary infertility, % 43.2(179/414) 33.3(4/12) 25.0(5/20)     
Gn duration, days 9.45 ± 1.60 10.00 ± 1.48 11.35 ± 1.60  < 0.001 0.703  < 0.001* 0.131
Gonadotropin dose, IU 2777 ± 698 2741 ± 731 3291 ± 860 0.013 1.00 0.010* 0.118
E2 on hCG day, pg/mL 1917 ± 971 3817 ± 2712 2180 ± 1243 0.024 0.024* 1.00 0.308
P on hCG day, ng/mL 0.82 ± 0.44 1.00 ± 0.39 0.99 ± 0.43 0.042 0.203 0.214 1.00
No. of oocytes retrieved 6.77 ± 3.54 9.58 ± 5.33 8.85 ± 4.21 0.015 0.150 0.086 1.00
No. of MII oocytes 6.03 ± 3.30 9.33 ± 5.50 7.55 ± 3.44 0.015 0.077 0.161 1.00
Oocyte maturation rate 0.89 ± 0.15 0.96 ± 0.08 0.88 ± 0.14 0.218    
The number of 2PN 4.19 ± 2.76 6.42 ± 4.06 4.65 ± 2.98 0.090    
Normal fertilization rate 0.65 ± 0.26 0.70 ± 0.19 0.56 ± 0.22 0.124    
blastocyst formation rate 0.61 ± 0.35 0.52 ± 0.37 0.66 ± 0.24 0.686    
No. of available embryos 4.17 ± 2.72 6.58 ± 3.58 4.70 ± 2.60 0.028 0.041* 0.798 0.604
Available embryo rate 0.66 ± 0.29 0.73 ± 0.15 0.57 ± 0.21 0.137    
No. of embryos transferred 0.93 ± 0.75 1.00 ± 0.85 1.10 ± 0.91 0.631    
Endometrial thickness, mm 10.81 ± 2.49 11.23 ± 2.21 12.18 ± 2.52 0.032 1.00 0.038* 1.00
Cumulative live birth rate, % 35.5(147/414) 58.3(7/12) 40.0(8/20) 0.255    
Live birth rate, %b 23.0(95/413) 41.7(5/12) 25.0(5/20) 0.289    
Live birth rate, %c 33.6(95/283) 62.5(5/8) 38.5(5/13) 0.208    
Clinical pregnancy rate, %b 27.8(115/414) 41.7(5/12) 30.0(6/20) 0.510    
Clinical pregnancy rate, %c 40.5(115/284) 62.5(5/8) 46.2(6/13) 0.432    
  1. * Significant differences after Bonferroni correction (P < 0.05)
  2. b Per started cycle
  3. c Per embryo transfer