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Table 3 Basic and cycle characteristics and pregnancy outcomes in the different controlled ovarian stimulation protocols in Group 3

From: Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients

Variable

GnRH Antagonist(A)

Long GnRH-a(B)

GnRH-a ultra-long(C)

Overall p value

A vs B

A vs C

B vs C

Number of patients, n (%)

414(92.8)

12(2.7)

20(4.5)

    

Maternal age, y

33.21 ± 4.80

34.08 ± 4.30

31.80 ± 4.94

0.328

   

Body mass index, kg/m2

21.74 ± 2.87

21.73 ± 2.61

21.85 ± 2.38

0.965

   

Baseline FSH, mIU/mL

8.62 ± 2.80

7.18 ± 1.55

7.53 ± 2.15

0.030

1.00

0.134

0.221

Antral follicle count (AFC)

3.32 ± 0.91

3.17 ± 1.40

3.25 ± 1.33

0.828

   

AMH level, ng/ml

2.38 ± 1.32

4.01 ± 2.45

3.28 ± 1.75

0.002

0.044*

0.025*

1.00

Duration of infertility, years, median (IQR)

3.00(2.00–5.00)

3.00(1.00–4.00)

2.00(1.00–4.00)

0.276

   

Infertility diagnosis

   

0.224

   

Primary infertility, %

56.8(235/414)

66.7(8/12)

75.0(15/20)

    

Secondary infertility, %

43.2(179/414)

33.3(4/12)

25.0(5/20)

    

Gn duration, days

9.45 ± 1.60

10.00 ± 1.48

11.35 ± 1.60

 < 0.001

0.703

 < 0.001*

0.131

Gonadotropin dose, IU

2777 ± 698

2741 ± 731

3291 ± 860

0.013

1.00

0.010*

0.118

E2 on hCG day, pg/mL

1917 ± 971

3817 ± 2712

2180 ± 1243

0.024

0.024*

1.00

0.308

P on hCG day, ng/mL

0.82 ± 0.44

1.00 ± 0.39

0.99 ± 0.43

0.042

0.203

0.214

1.00

No. of oocytes retrieved

6.77 ± 3.54

9.58 ± 5.33

8.85 ± 4.21

0.015

0.150

0.086

1.00

No. of MII oocytes

6.03 ± 3.30

9.33 ± 5.50

7.55 ± 3.44

0.015

0.077

0.161

1.00

Oocyte maturation rate

0.89 ± 0.15

0.96 ± 0.08

0.88 ± 0.14

0.218

   

The number of 2PN

4.19 ± 2.76

6.42 ± 4.06

4.65 ± 2.98

0.090

   

Normal fertilization rate

0.65 ± 0.26

0.70 ± 0.19

0.56 ± 0.22

0.124

   

blastocyst formation rate

0.61 ± 0.35

0.52 ± 0.37

0.66 ± 0.24

0.686

   

No. of available embryos

4.17 ± 2.72

6.58 ± 3.58

4.70 ± 2.60

0.028

0.041*

0.798

0.604

Available embryo rate

0.66 ± 0.29

0.73 ± 0.15

0.57 ± 0.21

0.137

   

No. of embryos transferred

0.93 ± 0.75

1.00 ± 0.85

1.10 ± 0.91

0.631

   

Endometrial thickness, mm

10.81 ± 2.49

11.23 ± 2.21

12.18 ± 2.52

0.032

1.00

0.038*

1.00

Cumulative live birth rate, %

35.5(147/414)

58.3(7/12)

40.0(8/20)

0.255

   

Live birth rate, %b

23.0(95/413)

41.7(5/12)

25.0(5/20)

0.289

   

Live birth rate, %c

33.6(95/283)

62.5(5/8)

38.5(5/13)

0.208

   

Clinical pregnancy rate, %b

27.8(115/414)

41.7(5/12)

30.0(6/20)

0.510

   

Clinical pregnancy rate, %c

40.5(115/284)

62.5(5/8)

46.2(6/13)

0.432

   
  1. * Significant differences after Bonferroni correction (P < 0.05)
  2. b Per started cycle
  3. c Per embryo transfer