Fig. 2
From: CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
CXCL2 promotes cell resistance to cisplatin in EOC by an autocrine mechanism. A and B) IC50 increased in co-cultured EOC cells. C and D CXCL2 expression level in cell culture supernatant. E IC50 in EOC cells respectively incubating with recombinant CXCL2 (CXCL2, 50 ng/ml) PBS (NC) for 6 h. F IC50 in EOC cells respectively incubating with CXCL2 neutralizing antibody (CXCL2 Ab) (5 µg/mL) and the control IgG antibody (IgG Ab) for 6 h G IC50 in EOC cells respecectively pretreating with CXCR2-specific inhibitor, SB225002 (10 μM) and DMSO for 6 h