Fig. 5
From: CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
CXCL2 promotes cell resistance to cisplatin in EOC by mediating ATR/CHK1 signaling pathway. A-D ATR and CHK1 were found up-regulated in platinum-resistant EOC tissues and cell lines. E and F The addition of CHK1 inhibitor, SAR-020106 (1 μM, pretreated for 6 h) weakened chemoresistance in cisplatin-resistant cells. G-I ATR and CHK1 expression were found up-regulated in cells with CXCL2 overexpression. J-L ATR and CHK1 expression were found down-regulated in cells with CXCL2 knocking-down. M and N The addition of SAR-020106 alleviated the chemoresistance in EOC cells with CXCL2 overexpressing. Abbreviation: R: resistant samples; S: sensitive samples; SAR: SAR-020106