Fig. 5
From: Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin
Down-regulation of GSTT1 decreased DNA damage repair molecules Topo I. A Western blot was used to detect the expression of GSTT1 and Topo I protein in taxol / carboplatin-resistant ovarian cell lines treated with taxol and carboplatin for 48 h. B Topo I protein levels in shGSTT1–1/2 transfected cells were analyzed. C. GSTT1 interacted with Topo I in co-immunoprecipitation experiment