Fig. 2

CircSETDB1 knockdown repressed SOC cell processes. A The interfering efficiency of si-circSETDB1#1, si-circSETDB1#2 and si-circSETDB1#3 was determined by qRT-PCR in A2780 and SKOV3 cells. B and C The effect of circSETDB1 knockdown on cell proliferation was revealed by CCK-8 and EDU assays in A2780 and SKOV3 cells. D The impact of circSETDB1 depletion on the apoptosis of A2780 and SKOV3 cells was determined by flow cytometry analysis. E and F Transwell invasion and wound-healing assays were employed to investigate the impacts of circSETDB1 downregulation on the invasion and migration of A2780 and SKOV3 cells, respectively. G Western blot analysis was performed to demonstrate the effect of circSETDB1 depletion on the protein abundance of MMP9 and MMP2 in A2780 and SKOV3 cells. *P < 0.05