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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics

Fig. 2

PARP1 inhibitor induced protein response profile in Ovsaho cells. (a) Number of protein groups detected by MS for each perturbation condition, three biological replicates per condition. Numbers are reported as mean of the three biological replicates and error bars show standard deviation for each condition. (b) Identification of PARP1i induced proteins whose expression is significantly changed compared to control DMSO treatment. Volcano plot of statistical significance against log2 protein expression change between PARP1i-treated versus control cells after 72 h. In green are significantly expressed proteins with log2ratio (PARP1i/DMSO) ≤ − 0.5 or ≥ 0.5 with p-value ≤0.05 (FDR < 0.2) and in blue proteins with transcriptional activity (STable1). (c) PARP1i-responsive proteins involved in pro-proliferative or anti-proliferative processes and possible interpretation for their relevance to sensitivity and resistance to PARP1i based on their proliferative function and protein expression change level upon PARP1i treatment relative to control (DMSO) treatment. If a pro-proliferative protein (or a protein with pro-proliferative functions) was upregulated upon PARPi treatment, it was considered as marker of resistance to PARPi; if it was downregulated, it was considered sensitive to PARPi. The reverse holds for the anti-proliferative proteins

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