Fig. 2

Circ_0061140 silencing repressed the PTX resistance and development of ovarian cancer. (A) The knockdown efficiency of circ_0061140 and circ_0061140 was detected by qRT-PCR in PTX-resistant SKOV3 and HeyA8 cells. (B and C) The effects of circ_0061140 silencing on cell viability after PTX exposure (0.1, 0.5, 1, 5, 10, 50 and 100 nM) were determined by MTT assay in PTX-resistant SKOV3 and HeyA8 cells. (D-F) The impact of circ_0061140 knockdown on cell proliferation was revealed by CCK-8 and colony formation assays in PTX-resistant SKOV3 and HeyA8 cells. (G) Flow cytometry analysis was performed to unveil the impact of circ_0061140 silencing on the apoptosis of PTX-resistant SKOV3 and HeyA8 cells. (H and I) The influences of circ_0061140 absence on the migration and invasion of PTX-resistant SKOV3 and HeyA8 cells were investigated by transwell assay. *P < 0.05