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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer

Fig. 3

Circ_0061140 was a sponge of miR-136. (A) The binding sites between circ_0061140 and miR-136 were predicted by interactome online database. (B and C) Dual-luciferase reporter assay was performed to detect luciferase activity in PTX-resistant SKOV3 and HeyA8 cells. (D and E) MiR-136 expression was detected by qRT-PCR in PTX-resistant ovarian cancer tissues (N = 20), PTX-sensitive ovarian cancer tissues (N = 19), SKOV3 and HeyA8 cells as well as PTX-resistant SKOV3 and HeyA8 cells. (F) The impacts between circ_0061140 knockdown and miR-136 repression on miR-136 expression were revealed by qRT-PCR in PTX-resistant SKOV3 and HeyA8 cells. (G) Spearman correlation analysis was conducted to assess the linear relationship between circ_0061140 and miR-136 expressions. *P < 0.05

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