Fig. 4

Circ_0061140 regulated the progression and PTX sensitivity of ovarian cancer by sponging miR-136. (A and B) The impacts between circ_0061140 knockdown and miR-136 depletion on cell viability after PTX treatment were revealed by MTT assay in PTX-resistant SKOV3 and HeyA8 cells. (C-E) The influences between circ_0061140 knockdown and miR-136 silencing on the proliferation of PTX-resistant SKOV3 and HeyA8 cells were explained by CCK-8 and colony formation assays. (F) Flow cytometry analysis was carried out to investigate the effects between circ_0061140 knockdown and miR-136 downregulation on the apoptosis of PTX-resistant SKOV3 and HeyA8 cells. (G and H) Transwell assay was performed to investigate the influences between circ_0061140 silencing and miR-136 RNAi on cell migration and invasion in PTX-resistant SKOV3 and HeyA8 cells. *P < 0.05