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Fig. 6 | Journal of Ovarian Research

Fig. 6

From: Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer

Fig. 6

MiR-136 suppressed cell proliferation, migration and invasion, and improved cell sensitivity to PTX and induced cell apoptosis by binding to CBX2 in ovarian cancer. (A and B) The impacts between miR-136 and CBX2 on the IC50 value of PTX were determined by MTT assay in PTX-resistant SKOV3 and HeyA8 cells. (C-E) The effects between miR-136 and CBX2 overexpression on the proliferation of PTX-resistant SKOV3 and HeyA8 cells were determined by CCK-8 and colony formation assays. (F) Flow cytometry analysis was performed to investigate the influences between miR-136 and CBX2 on the apoptosis of PTX-resistant SKOV3 and HeyA8 cells. (G and H) Transwell assay was carried out to investigate the effects between miR-136 and CBX2 on the migration and invasion of PTX-resistant SKOV3 and HeyA8 cells. *P < 0.05

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