Fig. 2

Schematic summary of the overall treatment and imaging schedule for the in vivo study. All mice were innoculated with ID8-L4 cells (Day -35) and were imaged (I) and treated with cisplatin (C) 2 and 3 weeks (Days -21 and -14) later. The animals were imaged 4 weeks after innoculation (Day -7) and one week later (Day 0) were divided into 2 primary treatment arms; one arm (n = 40 mice) underwent interval cytoreductive surgery (ICS) and the other arm (n = 40) were anesthetized (A) but left intact. At Day 0, a subset of 10 mice from each arm was treated with cisplatin. One week later (Day 7), all mice were imaged and a second subset of 10 animals from each arm was treated with cisplatin. One week later (Day 14) all mice were reimaged. Two weeks later (Day 28), a third subset of 8 or 10 mice from the remaining animals in each arm were treated with cisplatin and the remaining animals (n = 9) were left untreated. All groups were reimaged 35 and 42 days after surgery/anesthesia. The number and percentage of mice surviving to day 42 in each group and the two primary arms (ICS and A) is indicated