Fig. 2

Changes in the estrous cycle after chronic exposure to PFHxS. A A representative graph of estrous from each group, 10 days before PFHxS administration and 42 days during the PFHxS treatment. Spots connected separately represent the diestrus time (0), proestrus (1), or estrus (2). * persistent diestrus; ↓ proestrus loss. B The average length (day) of a single estrous cycle. C The average time (day) of proestrus (P), estrus (E), and diestrus (D) separately, per estrous cycle. **P < 0.01 vs. the control mice (n = 6/group, one-way ANOVA)