Fig. 4

Ghrelin enhanced the suppression of cisplatin on tumor growth in vivo. Mice were subcutaneously injected with HO-8910 PM ovarian cancer cells. One week after injection, mice were treated with PBS (control group), ghrelin, cisplatin and the combination of ghrelin with cisplatin every 4 days. A Images of the excised tumors from nude mice. n = 13 each group. B Average growth curves of tumors in nude mice. C Tumor weights of the excised tumors. D Body weight curves of the recipient mice. The data are presented as mean ± SEM. * p < 0.05, **p < 0.01, ***p < 0.001versus control group. #p < 0.01 versus DDP group