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Fig. 6 | Journal of Ovarian Research

Fig. 6

From: LncRNA MNX1-AS1 promotes ovarian cancer process via targeting the miR-744-5p/SOX12 axis

Fig. 6

SOX12 is a target gene of miR-744-5p. A The predicted binding sequence of miR-744-5p and SOX12 3’UTR, and the mutated sequence of SOX12. B Luciferase activity was detected in SKOV-3 and OVCAR-3 cells co-transfected with SOX12 WT or SOX12 Mut vector and NC mimics or miR-744-5p mimics. C RT-qPCR detected the expression of SOX12 in OC tumor tissues and non-tumor tissues. D RT-qPCR detected the expression of SOX12 in OC cells and normal ovarian cells. NC mimics and miR-744-5p mimics were transfected into SKOV-3 and OVCAR-3 cells, respectively. The expression of SOX12 was detected by RT-qPCR (E) and western blot (F). G Correlation analysis of SOX12 and miR-744-5p expression levels in OC tumor tissues. *P<0.05, **P<0.01, the difference comparison was compared with control group cells and tissues. Error bars were represented the mean ± SD in three independent repetitions

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