Skip to main content

Table 2 Results of all conducted meta-analysis

From: Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses

Variables Measure of Association Odds Ratio (95 % CI) P-value I2 % No. of study in analysis
Nutritional factors
Alcohol use RR 1.015 (0.974 – 1.052) 0.485 0.01 3
Coffee intake OR 1.106 (1.009 – 1.211) 0.030 0.00 4
RR 1.036 (0.967 – 1.109) 0.317 0.00 3
Egg intake RR 1.147 (1.045 – 1.250) <0.001 17.73 2
Fat intake RR 1.188 (1.090 – 1.296) <0.001 0.00 3
Fiber intake OR 0.760 (0.714 – 0.810) <0.001 0.00 3
Milk intake RR 1.016 (0.664 – 1.554) 0.941 0.08 2
Tea intake OR 0.833 (0.741 – 0.936) 0.002 0.00 3
RR 0.856 (0.779 – 0.959) 0.005 0.00 2
Vegetables intake RR 0.896 (0.837 – 0.958) <0.001 0.00 2
Drug use and Medical history
Aspirin OR 0.894 (0.854 – 0.935) <0.001 0.00 3
Metformin RR 0.718 (0.602 – 0.855) <0.001 0.00 3
NSAIDs RR 0.898 (0.819 – 0.984) 0.020 0.00 3
Oral contraceptive OR 0.655 (0.515 – 0.833) <0.001 78.23 2
Statin RR 0.849 (0.749 – 0.962) 0.010 0.00 2
Hormone therapy (estrogen) RR 1.305 (1.210 – 1.407) <0.001 0.00 2
Hormone therapy (Overall) RR 1.057 (1.030 – 1.400) <0.001 94.44 4
Hormone therapy (estrogen-progestin) OR 1.190 (1.043 – 1.357) 0.009 82.24 2
Hysterectomy OR 0.863 (0.745 – 0.999) 0.049 67.12 4
Tubal ligation OR 0.693 (0.657 – 0.731) <0.001 0.00  
Diseases
Diabetes RR 1.24 (1.32 – 1.35) <0.001 0.00 3
Endometriosis OR 1.433 (1.294 – 1.586) <0.001 3.05 2
Poly cystic ovarian syndrome OR 1.580 (1.081 – 2.310) 0.018 29.48 2
Genetic factors
Asn680Ser OR 1.120 (0.594 – 2.110) 0.726 86.32 2
BRCA2 N372H rs144848 OR 1.079 (1.018 – 1.143) 0.010 44.61 4
BSML rs1544410 OR 1.078 (1.024 – 1.153) 0.004 0.00 8
ESR2 rs3020450 OR 0.818 (0.719 – 1.040) 0.151 61.20 2
Fokl rs2228570 OR 1.123 (1.089 – 1.157) <0.001 0.00 8
GSTM1 OR 1.015 (0.928 – 1.111) 0.741 0.00 2
MTHFR A1298C OR 0.997 (0.943 – 1.054) 0.907 0.00 3
MTHFR C677T OR 1.077 (1.032 – 1.124) <0.001 45.55 9
NFƙB1 OR 1.680 (1.08 – 2.62) 0.020 69.07 2
P16INK4a OR 2.657 (1.173 – 6.014) 0.019 51.28 2
RAD51 135G-C OR 0.996 (0.922 – 1.075) 0.910 0.00 4
ERCC1 rs11615 OR 0.987 (0.756 – 1.287) 0.920 0.00 2
ERCC2 rs13181 OR 1.42 (1.15 – 1.76) 0.001 0.00 2
VGEGF rs699947 OR 0.983 (0.644 – 1.502) 0.938 78.04 2
VDR rs731236 OR 0.996 (0.882 – 1.125) 0.842 56.81 6
FASL rs763110 OR 0.640 (0.520 – 0.788) <0.001 <0.01 2
VEGFA rs833061 OR 0.834 (0.324 – 2.149) 0.707 76.02 2
RAD51 rs1801320 OR 0.656 (0.349 – 1.232) 0.189 41.43 3
FAS/APO-1 rs2234767 OR 1.001 (0.956 – 1.068) 0.982 0.00 3
MMP-12 rs2276109 OR 1.588 (0.694 – 3.630) 0.273 88.80 2
VEGF rs3025039 OR 0.869 (0.719 – 1.04) 0.144 0.00 2
VDR rs7975232 OR 0.990 (0.901 – 1.088) 0.842 0.00 5
VDR rs11568820 OR 1.164 (1.087 – 1.248) <0.001 0.00 4
XRCC2r rs3218536 OR 0.887 (0.750 – 1.050) 0.163 51.57 3
Other factors
Acrylamide RR 0.994 (0.930 – 1.063) 0.865 0.00 2
Obesity RR 1.274 (1.194 – 1.36) <0.001 0.00 2
Overweight OR 1.079 (1.041 – 1.119) <0.001 24.04 3
RR 1.071 (1.041 – 1.102) <0.001 0.00 3
Height RR 1.128 (1.064 – 1.196) <0.001 87.71 3
Weight RR 1.067 (0.977 – 1.165) 0.149 74.99 2
Smoking RR 1.311 (0.847 – 2.029) 0.225 98.13 3
Recreational physical activity RR 0.830 (0.745 – 0.925) <0.001 0.00 3
Perineal talc OR 1.297 (1.242 – 1.355) <0.001 0.00 2
RR 1.250)1.177 – 1.327) <0.001 38.11 2
Breast feeding OR 0.719 (0.679 – 0.762) <0.001 4.63 4