Table 2 Results of all conducted meta-analysis

Nutritional factors

Alcohol use

RR

1.015 (0.974 – 1.052)

0.485

0.01

3

Coffee intake

OR

1.106 (1.009 – 1.211)

0.030

0.00

4

RR

1.036 (0.967 – 1.109)

0.317

0.00

3

Egg intake

RR

1.147 (1.045 – 1.250)

<0.001

17.73

2

Fat intake

RR

1.188 (1.090 – 1.296)

<0.001

0.00

3

Fiber intake

OR

0.760 (0.714 – 0.810)

<0.001

0.00

3

Milk intake

RR

1.016 (0.664 – 1.554)

0.941

0.08

2

Tea intake

OR

0.833 (0.741 – 0.936)

0.002

0.00

3

RR

0.856 (0.779 – 0.959)

0.005

0.00

2

Vegetables intake

RR

0.896 (0.837 – 0.958)

<0.001

0.00

2

Drug use and Medical history

Aspirin

OR

0.894 (0.854 – 0.935)

<0.001

0.00

3

Metformin

RR

0.718 (0.602 – 0.855)

<0.001

0.00

3

NSAIDs

RR

0.898 (0.819 – 0.984)

0.020

0.00

3

Oral contraceptive

OR

0.655 (0.515 – 0.833)

<0.001

78.23

2

Statin

RR

0.849 (0.749 – 0.962)

0.010

0.00

2

Hormone therapy (estrogen)

RR

1.305 (1.210 – 1.407)

<0.001

0.00

2

Hormone therapy (Overall)

RR

1.057 (1.030 – 1.400)

<0.001

94.44

4

Hormone therapy (estrogen-progestin)

OR

1.190 (1.043 – 1.357)

0.009

82.24

2

Hysterectomy

OR

0.863 (0.745 – 0.999)

0.049

67.12

4

Tubal ligation

OR

0.693 (0.657 – 0.731)

<0.001

0.00

Diseases

Diabetes

RR

1.24 (1.32 – 1.35)

<0.001

0.00

3

Endometriosis

OR

1.433 (1.294 – 1.586)

<0.001

3.05

2

Poly cystic ovarian syndrome

OR

1.580 (1.081 – 2.310)

0.018

29.48

2

Genetic factors

Asn680Ser

OR

1.120 (0.594 – 2.110)

0.726

86.32

2

BRCA2 N372H rs144848

OR

1.079 (1.018 – 1.143)

0.010

44.61

4

BSML rs1544410

OR

1.078 (1.024 – 1.153)

0.004

0.00

8

ESR2 rs3020450

OR

0.818 (0.719 – 1.040)

0.151

61.20

2

Fokl rs2228570

OR

1.123 (1.089 – 1.157)

<0.001

0.00

8

GSTM1

OR

1.015 (0.928 – 1.111)

0.741

0.00

2

MTHFR A1298C

OR

0.997 (0.943 – 1.054)

0.907

0.00

3

MTHFR C677T

OR

1.077 (1.032 – 1.124)

<0.001

45.55

9

NFƙB1

OR

1.680 (1.08 – 2.62)

0.020

69.07

2

P16INK4a

OR

2.657 (1.173 – 6.014)

0.019

51.28

2

RAD51 135G-C

OR

0.996 (0.922 – 1.075)

0.910

0.00

4

ERCC1 rs11615

OR

0.987 (0.756 – 1.287)

0.920

0.00

2

ERCC2 rs13181

OR

1.42 (1.15 – 1.76)

0.001

0.00

2

VGEGF rs699947

OR

0.983 (0.644 – 1.502)

0.938

78.04

2

VDR rs731236

OR

0.996 (0.882 – 1.125)

0.842

56.81

6

FASL rs763110

OR

0.640 (0.520 – 0.788)

<0.001

<0.01

2

VEGFA rs833061

OR

0.834 (0.324 – 2.149)

0.707

76.02

2

RAD51 rs1801320

OR

0.656 (0.349 – 1.232)

0.189

41.43

3

FAS/APO-1 rs2234767

OR

1.001 (0.956 – 1.068)

0.982

0.00

3

MMP-12 rs2276109

OR

1.588 (0.694 – 3.630)

0.273

88.80

2

VEGF rs3025039

OR

0.869 (0.719 – 1.04)

0.144

0.00

2

VDR rs7975232

OR

0.990 (0.901 – 1.088)

0.842

0.00

5

VDR rs11568820

OR

1.164 (1.087 – 1.248)

<0.001

0.00

4

XRCC2r rs3218536

OR

0.887 (0.750 – 1.050)

0.163

51.57

3

Other factors

Acrylamide

RR

0.994 (0.930 – 1.063)

0.865

0.00

2

Obesity

RR

1.274 (1.194 – 1.36)

<0.001

0.00

2

Overweight

OR

1.079 (1.041 – 1.119)

<0.001

24.04

3

RR

1.071 (1.041 – 1.102)

<0.001

0.00

3

Height

RR

1.128 (1.064 – 1.196)

<0.001

87.71

3

Weight

RR

1.067 (0.977 – 1.165)

0.149

74.99

2

Smoking

RR

1.311 (0.847 – 2.029)

0.225

98.13

3

Recreational physical activity

RR

0.830 (0.745 – 0.925)

<0.001

0.00

3

Perineal talc

OR

1.297 (1.242 – 1.355)

<0.001

0.00

2

RR

1.250)1.177 – 1.327)

<0.001

38.11

2

Breast feeding

OR

0.719 (0.679 – 0.762)

<0.001

4.63

4