Fig. 2
From: Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
The influence of circ-PLEKHM3 on the proliferation and apoptosis in curcumin-treated ovarian cancer cells. A Circ-PLEKHM3 expression was examined in tumor and normal tissues (n = 35). B Circ-PLEKHM3 level was measured in SKOV3, A2780 and IOSE-80 cells. C Circ-PLEKHM3 abundance was examined in SKOV3 and A2780 cells after stimulation of various concentrations of curcumin. D Circ-PLEKHM3 level was detected in cells with transfection of oe-circ-PLEKHM3 or vector. Colony-formation ability (E), apoptosis (F), and protein levels of c-caspase-3, PCNA and Bax (G) were examined in cells with transfection of oe-circ-PLEKHM3 or vector under the treatment of curcumin or DMSO. *P < 0.05