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Fig. 6 | Journal of Ovarian Research

Fig. 6

From: RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

Fig. 6

Circ_0000745 upregulates ERBB4 to mediate the PI3K/AKT signaling pathway in OC cells. A, transfection efficacy of sh-ERBB4 and oe-ERBB4 in ES-2 or SK-OV-3 cells examined by RT-qPCR; B, phosphorylation of AKT and PI3K in ES-2 and SK-OV-3 examined by western blot analysis; C, proliferation ability of ES-2 and SK-OV-3 cells examined by the CCK-8 assay; D, colony formation ability of ES-2 and SK-OV-3 cells measured by the colony formation assay; E, migration ability of ES-2 and SK-OV-3 cells examined by the wound-healing assay; F, invasion ability of ES-2 and SK-OV-3 cells determined by the Transwell assay; G, stem cell property of ES-2 and SK-OV-3 cells determined by the sphere formation assay. Data were exhibited as mean ± SD from three repetitions. Differences were analyzed by one-way ANOVA (A, D, E, F and G) or two-way ANOVA (B and C); *p < 0.05 vs. oe-circ + sh-NC; #p < 0.05 vs. sh-circ + oe-NC

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Journal of Ovarian Research

ISSN: 1757-2215

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