Fig. 5

miR-149-3p knockdown rescued the inhibitory effect of TIMP2 and CDKN1A silence. A-D. CCK-8 and colony formation assays were performed to detect the proliferation of A2780/DDP cells co-transfected with miR-149-3p inhibitor and sh-CDKN1A#2 (A-B) or sh-TIMP2#2. C-D. E-F. Western blot was performed to detect EMT of A2780/DDP cells co-transfected with miR-149-3p inhibitor and sh-CDKN1A#2 (E) or sh-TIMP2#2 (F). G-H. Wound healing assay was performed to detect the migration of A2780/DDP cells co-transfected with miR-149-3p inhibitor and sh-CDKN1A#2 (G) or sh-TIMP2#2 (H). I. Transwell assay was performed to detect the invasion of A2780/DDP cells co-transfected with miR-149-3p inhibitor and sh-CDKN1A#2 or sh-TIMP2#2. *P < 0.05. All experiments were repeated three times with similar results