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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: FPR2 participates in epithelial ovarian cancer (EOC) progression through RhoA-mediated M2 macrophage polarization

Fig. 2

(A, B) RT-qPCR showed that FPR2 mRNA and RhoAmRNA were significantly increased in OVCAR3−FPR2+ cell lines and decreased in Caov3−shFPR2 cell lines regardless of MMK-1 treatment (**P < 0.01). (C, D1) Western blot analysis showed that FPR2 protein was significantly increased in OVCAR3−FPR2+ cell lines and decreased in Caov3-shFPR2 cell lines and was remarkably increased after stimulation with MMK-1 in OVCAR3−FPR2+ cell lines (**P < 0.01). (C, D2) Western blot analysis showed that RhoA protein was significantly decreased in Caov3−shFPR2 cell lines but showed no statistical significance in the OVCAR3−FPR2+ group and the control group, whereas RhoA was significantly increased in OVCAR3−FPR2+ cell lines when stimulated with MMK-1 (**P < 0.01)

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