Fig. 4

(A) IL-4 expression was significantly increased in OVCAR3^−FPR2+ cell line supernatant compared with its control group (**P < 0.01), and IL-10 expression was significantly decreased in C3 + OVCAR3^−NC cell lines compared with OVCAR3^−NC cell lines (**P < 0.01). TNFα expression was significantly decreased in OVCAR3^−FPR2+ cell line supernatant compared with its control group (**P < 0.01), and TNFα expression was also significantly decreased in OVCAR3 cell lines treated with C3 transfection (**P < 0.01). TGF-β1 and IL-12 expression showed no significant difference in each group (P > 0.05). (B) IL-4, IL-10 and TGF-β1 expression was significantly decreased in Caov3^−shFPR2 cell line supernatants compared with the control group (**P < 0.01), and C3 transfection evidently decreased the secretion of IL-4, IL-10 and TGF-β1 in Caov3 cell lines (**P < 0.01). TNFα expression was significantly increased in the supernatant of Caov3^−shFPR2 cell lines compared with its control group (**P < 0.01), and C3 transferase decreased TNFα secretion in Caov3 cell lines (**P < 0.01). IL-12 expression was not significantly different between the groups (P > 0.05)