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Table 2 Effect of co-administration of nicotine and ginseng on estradiol and folliculogenesis

From: Ginseng alleviates folliculogenesis disorders via induction of cell proliferation and downregulation of apoptotic markers in nicotine-treated mice

Groups

Primordial

Follicle (n/f)

Primary follicle

(n/f)

Preantral follicle

(n/f)

Antral follicle

(n/f)

Corpus luteum

(n/f)

Healthy follicle

(n/f)

Atretic follicle

(n/f)

Control

11.14 ± 2.35

8.98 ± 0.32b

19.42 ± 0.50b

9.47 ± 0.32b

3.6 ± 0.35b

52.9 ± 0.79b

4.5 ± 0.54b

Sham

9.88 ± 1.32

8.99 ± 0.17b

18.76 ± 0.40b

9.29 ± 1.07b

3.06 ± 0.40b

51.7 ± 0.48b

4.9 ± 0.24b

Nicotine

7.43 ± 2.92

4.76 ± 0.17a

8.59 ± 0/95a

4.76 ± 0.89a

1.50 ± 0.22a

26.9 ± 0.56a

11/26 ± 0.89a

Nicotine + Ga

11.12 ± 1.71

7.64 ± 0.28ab

13.1 ± 0.71ab

8.02 ± 0.32b

2.46 ± 0.17

40.34 ± 0.71b

6.72 ± 0.45b

Nicotine + Gb

21.50 ± 5.18

8.26 ± 0.22b

15.53 ± 0.89ab

9.3 ± 0.32b

3.1 ± 0.14b

44.06 ± 0.7b

6.87 ± 0.30b

  1. Data are expressed as mean and standard error. (n/f): number /microscopic field. Ga: ginseng 0.5 g/kg, Gb: ginseng 1 g/kg. aSignificant data in compare with control: P = 0.001, bSignificant data in compare with nicotine P = 0.001