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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: High expression of TRIM24 predicts worse prognosis and promotes proliferation and metastasis of epithelial ovarian cancer

Fig. 5

TRIM24 facilitates cell migration and induces EMT in EOC. a Wound-healing experiments showed that knockdown of TRIM24 expression in SKOV3 cells could inhibit cell migration. b Wound-healing experiments showed that overexpression of TRIM24 in CaOV-3 cells could promote cell migration. c The histogram of the ratio of cell migration area to scratch area of a and b (****P < 0.0001). d Transwell experiments showed that knockdown of TRIM24 expression in SKOV3 cells could inhibit cell migration. e Transwell experiments showed that overexpression of TRIM24 in CaOV-3 cells could promote cell migration. f Counts of the transmembrane cells in c and d and the difference was statistically significant (****P < 0.0001, ***P < 0.001). g Western blot showed that knockdown of TRIM24 in SKOV3 cells could promote the expression of E-cadherin and inhibit the expression of N-cadherin, while overexpression of TRIM24 in CaOV-3 cells could promote the process of EMT

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Journal of Ovarian Research

ISSN: 1757-2215

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