Fig. 2

CircCDK17 silencing inhibited tumor development and glycolysis in CC. A The transfection efficiency of si-circCDK17 was determined by qRT-PCR in C-33A and HeLa cells. B and C The effect of circCDK17 knockdown on cell proliferation was illustrated by CCK-8 assay in C-33A and HeLa cells. D and E The impacts of circCDK17 silencing on the migration and invasion of C-33A and HeLa cells were demonstrated by transwell assay. F Flow cytometry analysis was performed to investigate the influence of circCDK17 knockdown on the apoptosis of C-33A and HeLa cells. G Lactate assay kit was employed to the influence of circCDK17 silencing on lactate production in C-33A and HeLa cells. H Glucose assay kit was used to determine the impact of circCDK17 knockdown on glucose uptake in C-33A and HeLa cells. I ATP detection kit was conducted to present the effect of circCDK17 silencing on ATP level in C-33A and HeLa cells. J and K Western blot was employed to illustrate the effects of circCDK17 downregulation on the protein expression levels of GLUT1 and HK2 in C-33A and HeLa cells. *P < 0.05