Fig. 4

MTHFD2 mutations in human ovarian cancer. A The pie chart generated by COSMIC summarizes the observed mutation types, including nonsense substitutions, missense substitutions, synonymous substitutions, inframe insertions, frameshift insertions, inframe deletions, frameshift deletions, and complex mutations. B As determined using cBioPortal, the MTHFD2 mutation frequency (0.34%) in patients with ovarian cancer