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Table 4 Univariate cox regression analysis for risk factors associated with PFS

From: Neoantigens and the tumor microenvironment play important roles in the prognosis of high-grade serous ovarian cancer

Variables

HR

CI (95%)

P value

Age (year)

Serum CA125 (IU/ml)

Neoantigen (<500nM)

1.010

1.000

1.050

0.960-1.060

0.999-1.000

1.010-1.080

0.6908

0.6151

0.0069

TMB

4.060

1.460-11.300

0.0073

Immune score

1.000

0.999-1.000

0.5977

ITH

1.020

1.000-1.050

0.0249

T cells

1.010

0.798-1.280

0.9241

CD8+ T cells

0.795

0.462-1.370

0.4074

Cytotoxic lymphocytes

1.090

0.894-1.330

0.3938

NK cells

0.556

0.273-1.130

0.1061

B cells

1.000

0.999-1.000

0.3662

Monocytes

1.020

0.922-1.130

0.6778

Myeloid dendritic cells

1.020

0.723-1.430

0.9185

Neutrophils

1.060

0.854-1.320

0.5943

Endothelial cells

0.931

0.807-1.070

0.3251

Fibroblasts

0.999

0.997-1.000

0.2074

  1. TMB tumor mutational burden, ITH intratumor heterogeneity