Fig. 3From: Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiencyDNA damage models induced by MMC. A Chromosomal breakages in the peripheral lymphocytes obtained from the proband (III-1) and an unrelated control. ↖ denotes the chromosome break point. B Average number of chromosomal breaks in different MMC concentrations. Number of * denotes the degree of difference; ns means nonsense. C Expression of FMN2, P21, and H2AX in different MMC concentrations. performed by Western blot. WT wild type; MT mutant typeBack to article page