A risk model of gene signatures for predicting platinum response and survival in ovarian cancer

Table 3 10 optimal feature genes contained in the SVM classifier

Gene	DE mRNA		DE CN		Variant
Gene	logFC	p.value	logFC	p.value	Chrom	Variant Position	Type	Variant Classification	Amino acids	Codons	Reference Allele	Tumor Allele	dbSNP_RS
CD209	0.358543	0.0142	−0.42485	0.012717	19	7,807,996	SNP	Missense	R	Agg/Cgg	C	T	rs11465393
CD274	0.437529	0.00976	0.460916	0.002227	9	5,462,907	SNP	Missense	G/V	gGg/gTg	G	T	novel
HIST1H3I	−0.43754	0.00255	0.30903	0.010138	6	27,839,796	SNP	Missense	P/LX	cca/cTca	A	G	novel
HIST1H4L	−0.43335	0.0143	0.30903	0.010138	6	27,841,216	SNP	Missense	T	acA/acG	C	T	novel
NLGN1	1.019701	0.00143	0.351201	0.004621	3	173,525,589	SNP	Missense	T/M	aCg/aTg	G	C	novel
NTRK3	−0.36699	0.0247	0.295746	0.007258	15	88,576,170	SNP	Silent	L	Ctg/Ttg	C	G	novel
						88,483,904	SNP	Nonsense	T	acG/acC	C	A	novel
						88,522,597	SNP	Intron	R/W	Cgg/Tgg	G	A	novel
						88,423,602	SNP	Missense	T	acG/acA	G	A	novel
						88,420,205	SNP	Missense	D/X	Gat/at	C	A	novel
						88,476,380	SNP	Missense	Y	taC/taT	A	T	novel
PNLDC1	−0.85134	0.000718	−0.34754	0.003742	6	160,240,313	SNP	Silent	I/M	atC/atG	G	C	novel
SLC22A3	−0.51215	0.0225	−0.30286	0.005976	6	160,872,083	SNP	Missense	Y/*	taC/taG	C	T	novel
SLC5A1	0.298462	0.00642	0.441319	0.001623	22	32,495,226	SNP	Nonsense	V	gtC/gtT	C	G	novel
SYNM	0.558712	0.00288	0.448385	0.001034	15	99,672,483	SNP	Silent	T/R	aCg/aGg	A	G	novel
						99,669,768	SNP	Silent	T	acC/acT	G	A	novel
						99,671,917	SNP	Missense	R	cgG/cgC	G	C	novel
						99,672,905	SNP	Missense	T/N	aCc/aAc	C	G	novel
						99,653,864	SNP	Silent	D/E	gaT/gaA	C	T	novel
						99,672,085	SNP	Missense	Y/H	Tac/Cac	G	T	novel

ISSN: 1757-2215