Fig. 4

Over-expression of circRHOBTB3 reverses miR-23a-3p-fostered malignancy in OC cells. A In the CCK8 assay, proliferation circRHOBTB3 competively reduced the proliferation of SKOV3 and OVCAR8 cells that miR-23a-3p increased (one-way ANOVA). B CircRHOBTB3 competitively stagnated cells in the G1 period that could be released by miR-23a-3p (one-way ANOVA). C Transwell matrigel invasion assay demonstrated that miR-23a-3p fostered the invasion ability of SKOV3 and OVCAR8 cells; however, when co-transfected with circRHOBTB3, this effect was significantly attenuated (one-way ANOVA). D Apoptosis assay was performed to show whether circRHOBTB3 could rescue miR-23a-3p’s inhibition of apoptosis (one-way ANOVA)