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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: miR-600 promotes ovarian cancer cells stemness, proliferation and metastasis via targeting KLF9

Fig. 3

miR-600 knockdown suppresses ovarian cancer cells proliferation and metastasis. A. The proliferation curves of miR-600 knockdown ovarian cancer cells and control cells was measured by using CCK-8 assays. B. Colony formation assays of miR-600 knockdown ovarian cancer cells and control cells. C. The proliferation of miR-600 knockdown ovarian cancer cells and control cells were performed by EdU immunofluorescence staining assay. D. HO8910 miR-600 sponge or control cells (2 × 106) were subcutaneously injected into nude mice (n = 6) for xenograft assay. Tumor growth curve and average weight in each group was shown. E. Representative images of H&E staining of HO8910 miR-600 sponge or control cells formed xenografted tumors. F. The migration ability of miR-600 knockdown ovarian cancer cells and control cells were performed utilizing polycarbonate membrane inserts in a 24-well plate. G. The invasive ability of miR-600 knockdown ovarian cancer cells and control cells was analyzed using Matrigel-coated Boyden chamber. H. HO8910 miR-600 sponge and its control cells were inoculated via tail vein for 12 weeks. The number of lung metastatic foci in each group (n = 6) were also calculated

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