Gene Symbol | Case 1 (R) | Case 2 (R) | Case 3 (R) | Case 4 (S) | Case 5 (S) |
---|
Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post |
---|
Genes mutated in > 1 platinum-resistant cases only (16) |
*ADGRV1/GPR98a | | X | | X | | | | | | |
*AOC1/ABP1a | | X | | | X | Xe | | | | |
ARHGAP5 | | | X | | | Xe | | | | |
*CSPG4a | X | | X | X | | | | | | |
KIR2DL1 | | X | | | X | | | | | |
KRTAP4-11 | X | | | | | Xe | | | | |
MMP9 | | X | X | | | | | | | |
*MTMR11c | | X | | | X | Xd | | | | |
MUC17c | | X | | | | Xe | | | | |
MUC20c | | X | | | | Xe | | | | |
*OR52N5c | | X | X | X | | | | | | |
PAK2c | | | | X | | Xe | | | | |
*PCDHB11c | | | X | X | | Xe | | | | |
*TMEM14Bc | | X | X | X | | | | | | |
TTN | | X | X | | | | | | | |
USP8 | | X | X | | | | | | | |
Genes mutated in > 1 platinum-sensitive cases only (5) |
*CYP2D6b | | | | | | | X | | X | |
*DNAH5b | | | | | | | X | X | X | |
FAM186A | | | | | | | | X | X | |
MACF1 | | | | | | | | X | X | |
NUTM1b | | | | | | | X | | X | |
- Genes that were recurrently mutated in either resistant or sensitive cases (irrespective of time point) are shown. Whether a non-synonymous exonic mutation was detected in pre-NACT and/or post-NACT samples from each case is indicated by an “X”. Specific mutations are included in Additional File 3. *included on targeted panel; agene mutated in pre-NACT samples from > 1 resistant cases but not sensitive cases (CSPG4); bgene mutated in pre-NACT samples from both sensitive cases but not resistant cases (CYP2D6, NUTM1, DNAH5); cgene mutated in post-NACT samples from > 1 resistant cases but not sensitive cases (ADGRV1, AOC1, MTMR11, MUC17, MUC20, OR52N5, PAK2, PCDHB11, TMEM14B); dgene mutated in both omental and ovarian post-NACT samples from Case 3 (MTMR11); egene mutated in only 1 post-NACT sample from Case 3 (AOC1, ARHGAP5, KRTAP4-11, MUC17, MUC20, PAK2, PCDHB11)