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Table 1 The main characteristics of the included studies in the meta-analysis

From: The diagnostic value of serum miR-21 in patients with ovarian cancer: a systematic review and meta-analysis

Study

Year

Country

detection method

case (control)

control (benign)

Age (median)

Time-consuming

tumor stage

Cut-off value

sensitivity

Specificity

TP

FP

FN

TN

QUADAS-2 scores

Zeng Y [29]

2016

China

RT-qPCR

40(82)

82(42)

49

1.5

I-IV

NR

0.675

0.7857

27

18

13

64

7

Mahmoud [30]

2018

Egypt

RT-qPCR

60(30)

30(0)

55.5

1

I, III-IV

1.005

0.967

0.8

58

6

2

24

9

Tang M [31]

2018

China

RT-qPCR

162(108)

108(0)

54.27

4

I-IV

1.46

0.842

0.705

136

32

26

76

5

Li HP [32]

2019

China

RT-qPCR

96(80)

80(80)

51.27

2

I-IV

1.73

0.7708

0.8125

74

15

22

65

8

You J [33]

2019

China

RT-qPCR

80(100)

100(50)

53.68

2

I-IV

2.13

0.788

0.92

63

8

17

92

7

Song KW [34]

2020

China

RT-qPCR

86(86)

86(0)

46.1

1

I-IV

1.027

0.763

0.856

66

12

20

74

9

  1. Abbreviations: TN true negative, TP true positive, FN false negative, FP false positive, NR not-reported, RT-qPCR real-time quantitative polymerase chain reaction, QUADAS-2 Quality Assessment of Diagnostic Accuracy Studies-2