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Table 3 The diagnostic performance and the comparison between the diagnostic performance of CA125, hsa_circ_0003972 + CA125, hsa_circ_0007288 + CA125 and circCOMBO + CA125

From: Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer

 

Best cut-off

AUC(95%CI)

Sensitivity (%)

Specificity

(%)

P-value

Comparison of AUC

Groups

P-value

CA125

38.825U/ml

0.824(0.739–0.908)

97

73

p < 0.0001

CA125 + circ-0003972

−

0.912(0.864–0.961)

78.3

90.0

NA

circ-0003972 vs. CA125

0.1201

circ-0003972 vs. circ-0003972 + CA125

p < 0.0001

CA125 vs. circ-0003972 + CA125

0.0781

CA125 + circ-0007288

−

0.918(0.869–0.968)

98.3

71.7

NA

circ-0007288 vs. CA125

0.5839

circ-0007288 vs. circ-0007288 + CA125

0.0011

CA125 vs. circ-0007288 + CA125

0.0613

CA125 + circCOMBO

−

0.923(0.878–0.968)

80.0

93.3

NA

circCOMBO vs. CA125

0.4947

circCOMBO vs. circCOMBO + CA125

p < 0.0001

CA125 vs. circCOMBO + CA125

0.0449