Fig. 1

Significant pathways associated with lifetime ovulatory years overall and stratified by menopausal status with FDR < 1.0 × 10^–5 in type II ovarian cancer tumor tissue in NHS, NHSII, and NEC studies (n = 234). Pathways associated with lifetime ovulatory years overall are presented in the order of statistical significance in the left figure including all tumors (adjusted p-value plotted on the x axis). Results of the same pathways when restricted to premenopausal and postmenopausal cases are presented in the middle and right figures, respectively. Upregulated pathways are denoted by red bubbles and downregulated pathways are denoted by blue bubbles. Cell cycle checkpoints pathway was removed in premenopausal women due to NES and p-values not calculated. Of note, “G2M_CHECKPOINT” is from Hallmarks of Cancer database and “G2_M_CHECKPOINTS” is from Reactome database