Fig. 2

Heatmap of genes associated with ovulatory years and its individual components in significantly associated inflammation/immune-related pathways. Of the genes included in the significant pathways (i.e., interferon gamma response, interferon alpha response, inflammatory response, TNAa signaling via NFkB, allograft rejection), individual genes associated with ovulatory years with unadjusted p-value < 0.05 were included in the heatmap. The top of the heatmap shows values for age at menarche (green), years of oral contraceptive use (purple), parity (yellow), age at menopause (orange; gray bars indicate premenopausal cases), and the summary ovulatory years (blue). A Heatmap including all type II ovarian cancer tumors in NHS/NHSII/NEC (n = 234) and B Heatmap restricting to type II ovarian cancer tumors from patients who were postmenopausal at time of diagnosis (n = 183)