Fig. 3

Heatmap of genes associated with ovulatory years in the proliferation-related pathways. Of the genes included in the significant pathways (i.e.E2F targets, G2M checkpoint, cell cycle checkpoints, cell cycle mitotic, DNA replication, separation of sister chromatids, mitotic metaphase and anaphase, S phase, G2 M checkpoints, M phase), individual genes associated with ovulatory years with unadjusted p-value < 0.05 were included in the heatmap. A Heatmap including all type II ovarian cancer tumors in NHS/NHSII/NEC (n = 234) and B Heatmap restricting to type II ovarian cancer tumors from patients who were premenopausal at time of diagnosis in NHS/NHSII/NEC (n = 51). Grey bars in age at menopause indicate premenopausal cases