Table 2 Significant pathways associated with lifetime ovulatory years with adjusted p-value < 1.0 × 10–5 in type II ovarian cancer tumor tissue in NHS, NHSII, and NEC (n = 234)
From: Lifetime ovulatory years and ovarian cancer gene expression profiles
Pathway names | Database | Number of genes | NES | Unadjusted p-value | FDR |
|---|---|---|---|---|---|
INTERFERON GAMMA RESPONSE | Hallmarks of cancer | 184 | -2.67 | 7.60 × 10–21 | 3.80 × 10–19 |
E2F TARGETS | Hallmarks of cancer | 196 | -2.62 | 5.62 × 10–20 | 1.41 × 10–18 |
G2M CHECKPOINT | Hallmarks of cancer | 192 | -2.48 | 1.35 × 10–16 | 2.25 × 10–15 |
INTERFERON ALPHA RESPONSE | Hallmarks of cancer | 92 | -2.52 | 1.54 × 10–12 | 1.93 × 10–11 |
CELL CYCLE CHECKPOINTS | REACTOME | 253 | -2.27 | 8.90 × 10–14 | 3.78 × 10–11 |
CELL CYCLE MITOTIC | REACTOME | 477 | -1.97 | 6.79 × 10–14 | 3.78 × 10–11 |
INFLAMMATORY RESPONSE | Hallmarks of cancer | 153 | -2.27 | 3.99 × 10–11 | 3.99 × 10–10 |
TNFA SIGNALING VIA NFKB | Hallmarks of cancer | 176 | -2.17 | 1.33 × 10–10 | 1.11 × 10–9 |
ALLOGRAFT REJECTION | Hallmarks of cancer | 142 | -2.17 | 9.30 × 10–10 | 6.64 × 10–9 |
DNA REPLICATION | REACTOME | 124 | -2.36 | 6.56 × 10–11 | 1.86 × 10–8 |
SEPARATION OF SISTER CHROMATIDS | REACTOME | 176 | -2.09 | 9.53 × 10–10 | 2.02 × 10–7 |
MITOTIC METAPHASE AND ANAPHASE | REACTOME | 221 | -2.04 | 2.87 × 10–9 | 4.06 × 10–7 |
S PHASE | REACTOME | 157 | -2.13 | 2.41 × 10–9 | 4.06 × 10–7 |
OXIDATIVE PHOSPHORYLATION | KEGG | 112 | -2.18 | 6.59 × 10–9 | 1.05 × 10–6 |
G2 M CHECKPOINTS | REACTOME | 131 | -2.18 | 1.38 × 10–8 | 1.67 × 10–6 |
M PHASE | REACTOME | 338 | -1.83 | 1.83 × 10–8 | 1.94 × 10–6 |
HYPOXIA | Hallmarks of cancer | 168 | -1.85 | 8.98 × 10–7 | 5.62 × 10–6 |
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | REACTOME | 161 | -2.01 | 9.21 × 10–08 | 8.69 × 10–06 |