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Table 1 Features different types of miRNA, their expression pattern, signaling pathways, functions, and target regulators

From: Role of different non-coding RNAs as ovarian cancer biomarkers

miRNA

Expression Pattern and No of Clinical Samples

Signaling pathways

Target Regulators

Function

References

miRNA-1

Downregulated

5 non-neoplastic ovarian tissues and 13 ovarian cancer specimens

Akt, ERK1/2

c-met

miRNA-1 takes part in tumor suppression by inhibiting the expression of c-met

[24]

miRNA-124

Downregulated

13 pairings of adjacent non-tumor tissues and ovarian cancer tissues

–

SphK1

Downregulation of SphK1 is supported by miR-124 which suppresses migration and invasion of Ovarian Cancer

[25]

miRNA-335

Downregulated

ovarian cancer tissues and non-tumor tissues in ten pairs

–

Bcl-W

In epithelial ovarian cancer, miR-335 is responsible for poor survival

[26]

miRNA-215

Downregulate

A total of 48 pairs of ovarian cancer tissues and non-tumor tissues were studied.

MAPK

NOB1

NOB1is helpful in inhibiting the growth of tumor cells with the help of miR-215

[27]

miRNA-429

Downregulated

A total of 72 pairs of ovarian cancer tissues and non-tumor tissue were used in this study.

–

ZEB1

Cisplatin sensitivity increases due to Overexpression of miR-429 which help in reducing autophagy-related protein anti-LC3A/Band Anti-ATG7

[28]

miRNA-200c

Upregulated

–

ZEB1

Inhibition of EMT in CD44 + CD117 + CSCs is supported by miR-200c overexpression which decreases ZEB1 expression.

[29]

miRNA-7

Upregulated

180 samples of ovarian cancer, 66 samples of normal ovarian tissue

AKT, ERK1

–

The overexpression of miR-7 in SKOV3 cells increases cell invasion and migration.

[22]

miRNA-25

miRNA-93

Downregulated

180 samples of ovarian cancer, 66 samples of normal ovarian tissue

AKT/ERK1

–

In SKOV3 cells, overexpression of miR-7 increases cell migration and invasion.

[22]

miRNA-137

Downregulated

There were 21 cases of serous adenocystic carcinoma, 14 cases of mucinous adenocystic carcinoma, and 29 cases of normal ovarian tissues.

–

XIAP

miR-137 promotes Epithelial Ovarian cells to undergo cisplatin-induced apoptosis.

[30]

miRNA-490-3p

Downregulated

139 samples of ovarian cancer, 17 samples of normal ovarian tissue

 

CDK1

Induced expression of p53 Cell cycle phases G1/SorG2/arrest and apoptosis is promoted by overexpression of MiR-490-3P and reduces cell invasion, migration, proliferation, and invasion.

[31]

miRNA-145

Downregulated

38 samples of ovarian cancer, 9 samples of normal ovarian tissue

–

TRIM2

miR-145 mediates inhibition of TRIM2 which leads to the up-regulation.

[32]

miRNA-92

-

3 pairs of ovarian cancer tissues and non-cancer tissues adjacent

Wnt/β-catenin, STAT3

DKK1

In epithelial ovarian cancer, the STAT3-miR-92a-DKK1 pathway has potential therapeutic applications for targeted therapy

[33]

let-7d-5p

Downregulated

76 pairings of non-tumor tissues and ovarian cancer tissues

p53

HMGA1

The proliferation in ovarian cancer cells is suppressed and chemosensitivity is restored through the let-7d-5p by activating the p53 signaling pathway and silencing HMGA1.

[34]

miRNA-206

Downregulated

50 samples of ovarian cancer tissues

AKT/mTOR

c-Met

mir-206 could suppressor through c-Met/AKT/ mTOR signaling pathway

[35]

miRNA-630

Upregulated

–

APAF-1

miR-630 targets APAF-1 in re-sensitizing the cells to chemotherapy.

[36]

miRNA-152

Downregulated

8 pairs of cancer tissues and adjacent non-cancerous tissues

–

FOXP1

The proliferation and migration in epithelial ovarian cancer cells are inhibited by miR-152 by targeting FOXP1.

[37]

miRNA-142-3p

Downregulated

There are 58 pairs of malignant and non-cancerous tissues in this study.

–

Sirtuin 1

The proliferation and chemoresistance in ovarian cancer could be inhibited by miR-142-3p by targeting SIRT1.

[38]

miRNA-221

Upregulated

There are 63 pairs of cancer tissues and surrounding non-tumor tissues in this study.

–

APAF-1

The proliferation of cells in OC is promoted by overexpression of miRNA-221 by targeting APAF 1.

[39]

miRNA-145-5p

Downregulated

-

Hippo

CTGF

Lower expression of miR-145-5p in Ovarian cancer is reviewed as a biomarker for diagnosis.

[40]

miRNA—199b-5p

Downregulated

79 EOC patient

Notch1

JAG1

Acquired chemoresistance in ovarian cancer is associated with miR-199b-5p via activating JAG1/ Notch1 signaling.

[41]

miRNA-141

Upregulated

132 fresh-frozen ovarian cancer samples

NF-kB

p38a MAPK, YAP1, KEAP1

In ovarian cancer cell lines, miR-141 overexpression can increase resistance to cisplatin. It also modulates cisplatin sensitivity by targeting KEAP1.

[42]

miRNA-424-5p

Downregulated

surgical resection of 83 primary and 19 matched normal tissues

E2F1-pRB

CCNE1

G0/G1 cell cycle arrest and proliferation of ovarian cancer cells are being done miR-424-5p by targeting CCNE1 mediated E2F1- pRb signaling pathway.

[43]