From: Role of different non-coding RNAs as ovarian cancer biomarkers
miRNA | Expression Pattern and No of Clinical Samples | Signaling pathways | Target Regulators | Function | References |
---|---|---|---|---|---|
miRNA-1 | Downregulated 5 non-neoplastic ovarian tissues and 13 ovarian cancer specimens | Akt, ERK1/2 | c-met | miRNA-1 takes part in tumor suppression by inhibiting the expression of c-met | [24] |
miRNA-124 | Downregulated 13 pairings of adjacent non-tumor tissues and ovarian cancer tissues | – | SphK1 | Downregulation of SphK1 is supported by miR-124 which suppresses migration and invasion of Ovarian Cancer | [25] |
miRNA-335 | Downregulated ovarian cancer tissues and non-tumor tissues in ten pairs | – | Bcl-W | In epithelial ovarian cancer, miR-335 is responsible for poor survival | [26] |
miRNA-215 | Downregulate A total of 48 pairs of ovarian cancer tissues and non-tumor tissues were studied. | MAPK | NOB1 | NOB1is helpful in inhibiting the growth of tumor cells with the help of miR-215 | [27] |
miRNA-429 | Downregulated A total of 72 pairs of ovarian cancer tissues and non-tumor tissue were used in this study. | – | ZEB1 | Cisplatin sensitivity increases due to Overexpression of miR-429 which help in reducing autophagy-related protein anti-LC3A/Band Anti-ATG7 | [28] |
miRNA-200c | Upregulated | – | ZEB1 | Inhibition of EMT in CD44 + CD117 + CSCs is supported by miR-200c overexpression which decreases ZEB1 expression. | [29] |
miRNA-7 | Upregulated 180 samples of ovarian cancer, 66 samples of normal ovarian tissue | AKT, ERK1 | – | The overexpression of miR-7 in SKOV3 cells increases cell invasion and migration. | [22] |
miRNA-25 miRNA-93 | Downregulated 180 samples of ovarian cancer, 66 samples of normal ovarian tissue | AKT/ERK1 | – | In SKOV3 cells, overexpression of miR-7 increases cell migration and invasion. | [22] |
miRNA-137 | Downregulated There were 21 cases of serous adenocystic carcinoma, 14 cases of mucinous adenocystic carcinoma, and 29 cases of normal ovarian tissues. | – | XIAP | miR-137 promotes Epithelial Ovarian cells to undergo cisplatin-induced apoptosis. | [30] |
miRNA-490-3p | Downregulated 139 samples of ovarian cancer, 17 samples of normal ovarian tissue | Â | CDK1 | Induced expression of p53 Cell cycle phases G1/SorG2/arrest and apoptosis is promoted by overexpression of MiR-490-3P and reduces cell invasion, migration, proliferation, and invasion. | [31] |
miRNA-145 | Downregulated 38 samples of ovarian cancer, 9 samples of normal ovarian tissue | – | TRIM2 | miR-145 mediates inhibition of TRIM2 which leads to the up-regulation. | [32] |
miRNA-92 | - 3 pairs of ovarian cancer tissues and non-cancer tissues adjacent | Wnt/β-catenin, STAT3 | DKK1 | In epithelial ovarian cancer, the STAT3-miR-92a-DKK1 pathway has potential therapeutic applications for targeted therapy | [33] |
let-7d-5p | Downregulated 76 pairings of non-tumor tissues and ovarian cancer tissues | p53 | HMGA1 | The proliferation in ovarian cancer cells is suppressed and chemosensitivity is restored through the let-7d-5p by activating the p53 signaling pathway and silencing HMGA1. | [34] |
miRNA-206 | Downregulated 50 samples of ovarian cancer tissues | AKT/mTOR | c-Met | mir-206 could suppressor through c-Met/AKT/ mTOR signaling pathway | [35] |
miRNA-630 | Upregulated | – | APAF-1 | miR-630 targets APAF-1 in re-sensitizing the cells to chemotherapy. | [36] |
miRNA-152 | Downregulated 8 pairs of cancer tissues and adjacent non-cancerous tissues | – | FOXP1 | The proliferation and migration in epithelial ovarian cancer cells are inhibited by miR-152 by targeting FOXP1. | [37] |
miRNA-142-3p | Downregulated There are 58 pairs of malignant and non-cancerous tissues in this study. | – | Sirtuin 1 | The proliferation and chemoresistance in ovarian cancer could be inhibited by miR-142-3p by targeting SIRT1. | [38] |
miRNA-221 | Upregulated There are 63 pairs of cancer tissues and surrounding non-tumor tissues in this study. | – | APAF-1 | The proliferation of cells in OC is promoted by overexpression of miRNA-221 by targeting APAF 1. | [39] |
miRNA-145-5p | Downregulated - | Hippo | CTGF | Lower expression of miR-145-5p in Ovarian cancer is reviewed as a biomarker for diagnosis. | [40] |
miRNA—199b-5p | Downregulated 79 EOC patient | Notch1 | JAG1 | Acquired chemoresistance in ovarian cancer is associated with miR-199b-5p via activating JAG1/ Notch1 signaling. | [41] |
miRNA-141 | Upregulated 132 fresh-frozen ovarian cancer samples | NF-kB | p38a MAPK, YAP1, KEAP1 | In ovarian cancer cell lines, miR-141 overexpression can increase resistance to cisplatin. It also modulates cisplatin sensitivity by targeting KEAP1. | [42] |
miRNA-424-5p | Downregulated surgical resection of 83 primary and 19 matched normal tissues | E2F1-pRB | CCNE1 | G0/G1 cell cycle arrest and proliferation of ovarian cancer cells are being done miR-424-5p by targeting CCNE1 mediated E2F1- pRb signaling pathway. | [43] |