Table 2 Depicts the clinical significance of different lncRNAs in ovarian cancer

H19

Chr11p15.5

2.3

In ovarian cancer, when H19 is highly expressed it triggers migration and invasion of tumor cells

[61]

HOTAIR

Chr12.q13.13

2.2

HOTAIR plays crucial role in chemoresistance and its increased sensitivity towards cisplatin causes autophagy in OC

[62]

X inactivate-specific transcript (XIST)

ChrX

17

XIST is found to be a potent biomarker for patients who respond to first-line chemotherapy because a high affinity is found between regulation of XIST and patient response to chemotherapy using paclitaxel.

[63]

UCA1

Chr19p13.12

1439

UCA1 is a dominant biomarker for several cancer types. Up-regulation of UCA1 is linked with progression-free survival (PFS) in ovarian cancer patients.

(Hong, Hou [64])

MALAT-1

Chr11q13

> 8000 nucleotides

Wnt/β-catenin signaling pathway is affected by; HOTAIR, MALAT-1 is, therefore, downregulation of MALAT-1 is used to inhibit OC cell viability, migration, and invasion,

[65]

Plasmacytoma variant translocation 1 (PVT1) PVT1

Chr8q24.21

1716 nucleotides

Progression of ovarian cancer is supported by PVT1 by silencing miR-214.

[66]

GASS

1q25.1.10

0.7

The expression of GAS5 is more prevalent in EOC than in normal ovarian epithelium tissue.

[67]

Homeobox protein D cluster antisense RNA 1 (HOXD-AS1

Chr2q31.2

Raised levels of HOXD-AS1 were adversely correlated with PFS and OS of EOC patients.

[68]

Sprouty RTK signaling antagonist (SPRY4-IT1)

Chr5q31.3

708

Progression of ovarian cancer might occur due to SPRY4-IT1 downregulation [119]. But still, the mechanism of this long codinglncRNAA is complicated, whether it acts as a tumor suppressor or an oncogene in ovarian tissue

[69]