Fig. 2

Screening of key genes for chemotherapy resistance in ovarian cancer and KEGG enrichment analysis. A Volcano plot of genes in ovarian cancer-related microarray GSE46169 (normal group, n = 3; tumor group, n = 27). B Volcano plots of genes in chemoresistance-related ovarian cancer cell-related microarray GSE15372 (cisplatin-sensitive group, n = 5; cisplatin-resistant group, n = 5). The red dots in Panels A and B represent significantly up-regulated genes, and the green dots indicate significantly down-regulated genes, black dots represent genes with insignificant expression differences. C The Venn diagram of the intersected genes in microarrays GSE46169 and GSE15372. D Bubble chart of KEGG enrichment analysis for 224 genes. The color of the dots indicates the p value, the size of the dots indicates the number of enriched targets, the x-axis indicates the number of enriched items, and the y-axis indicates the path name