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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Expression of voltage-gated Ca2+ channels, Insp3Rs, and RyRs in the immature mouse ovary

Fig. 5

Tissue distribution of specific immunolabelling for CaV2.1 and CaV2.2 voltage-gated Ca2+ channels in the early infantile ovary (PND 8). A: CaV2.1 specific immunostaining. a, b: Enlarged images from the square areas indicated in A. yellow asterisks: weak staining of few primordial oocytes near the plasma membrane. red asterisks: distinct CaV2.1 staining of oocytes and granulosa cells from primary and secondary follicles. blue arrows: cytoplasmic staining of granulosa cells close to the plasma membrane in primary follicles. yellow arrows: flat, perifollicular stromal cells next to secondary and early antral follicles show the strongest CaV2.1 immunolabeling. B: CaV2.2 specific immunostaining. c, d: Enlarged images from the square areas indicated in B. CaV2.2-specific staining is moderate throughout the ovary. yellow asterisks: few remaining primordial follicles. red asterisks: oocytes showing moderate CaV2.2 immunostaining: blue arrows: weakly stained granulosa cells surrounding oocytes from primary follicles. yellow arrows: patches of perifollicular cells around secondary and early antral follicles show the strongest CaV2.2 labeling. Calibration bar: 100 μm (A, B); 50 μm (a, b, c, d)

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